GRAP protein (Octodon degus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

GRAP

GRB2 related adaptor protein. (217 aa)

Predicted Functional Partners:

ENSODEP00000018443

0.979

MET

0.968

ENSODEP00000024866

0.968

GAB1

0.952

LCP2

0.932

PTPN6

0.920

PTPN11

0.916

INPPL1

0.911

CTLA4

0.908

TNK1

0.904

Your Current Organism:

Octodon degus

NCBI taxonomy Id: 10160
Other names: O. degus, degu

Export your current network:

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same PNG format, but at higher resolution

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTLA4	ENSODEP00000024866	ENSODEP00000012588	ENSODEP00000024866	Cytotoxic T-lymphocyte associated protein 4.	annotation not available	0.407
CTLA4	GRAP	ENSODEP00000012588	ENSODEP00000001519	Cytotoxic T-lymphocyte associated protein 4.	GRB2 related adaptor protein.	0.908
CTLA4	LCP2	ENSODEP00000012588	ENSODEP00000005557	Cytotoxic T-lymphocyte associated protein 4.	Lymphocyte cytosolic protein 2.	0.519
CTLA4	MET	ENSODEP00000012588	ENSODEP00000001269	Cytotoxic T-lymphocyte associated protein 4.	MET proto-oncogene, receptor tyrosine kinase.	0.525
CTLA4	PTPN11	ENSODEP00000012588	ENSODEP00000017041	Cytotoxic T-lymphocyte associated protein 4.	Protein tyrosine phosphatase non-receptor type 11.	0.994
CTLA4	PTPN6	ENSODEP00000012588	ENSODEP00000004384	Cytotoxic T-lymphocyte associated protein 4.	Protein tyrosine phosphatase non-receptor type 6.	0.993
ENSODEP00000018443	GRAP	ENSODEP00000018443	ENSODEP00000001519	annotation not available	GRB2 related adaptor protein.	0.979
ENSODEP00000018443	LCP2	ENSODEP00000018443	ENSODEP00000005557	annotation not available	Lymphocyte cytosolic protein 2.	0.999
ENSODEP00000018443	PTPN11	ENSODEP00000018443	ENSODEP00000017041	annotation not available	Protein tyrosine phosphatase non-receptor type 11.	0.974
ENSODEP00000018443	PTPN6	ENSODEP00000018443	ENSODEP00000004384	annotation not available	Protein tyrosine phosphatase non-receptor type 6.	0.972
ENSODEP00000024866	CTLA4	ENSODEP00000024866	ENSODEP00000012588	annotation not available	Cytotoxic T-lymphocyte associated protein 4.	0.407
ENSODEP00000024866	GAB1	ENSODEP00000024866	ENSODEP00000000451	annotation not available	GRB2 associated binding protein 1.	0.985
ENSODEP00000024866	GRAP	ENSODEP00000024866	ENSODEP00000001519	annotation not available	GRB2 related adaptor protein.	0.968
ENSODEP00000024866	INPPL1	ENSODEP00000024866	ENSODEP00000009305	annotation not available	Inositol polyphosphate phosphatase like 1.	0.719
ENSODEP00000024866	MET	ENSODEP00000024866	ENSODEP00000001269	annotation not available	MET proto-oncogene, receptor tyrosine kinase.	0.921
ENSODEP00000024866	PTPN11	ENSODEP00000024866	ENSODEP00000017041	annotation not available	Protein tyrosine phosphatase non-receptor type 11.	0.927
ENSODEP00000024866	PTPN6	ENSODEP00000024866	ENSODEP00000004384	annotation not available	Protein tyrosine phosphatase non-receptor type 6.	0.927
GAB1	ENSODEP00000024866	ENSODEP00000000451	ENSODEP00000024866	GRB2 associated binding protein 1.	annotation not available	0.985
GAB1	GRAP	ENSODEP00000000451	ENSODEP00000001519	GRB2 associated binding protein 1.	GRB2 related adaptor protein.	0.952
GAB1	INPPL1	ENSODEP00000000451	ENSODEP00000009305	GRB2 associated binding protein 1.	Inositol polyphosphate phosphatase like 1.	0.470