STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Atg16l2Autophagy-related protein 16-2. (623 aa)    
Predicted Functional Partners:
ATG5
Autophagy protein 5; Involved in autophagic vesicle formation.
   
 0.997
Atg12
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.
    
 0.996
Wipi1
WD repeat domain phosphoinositide-interacting protein 1.
   
 0.988
Atg3
Autophagy-related protein 3.
   
 0.985
Wipi2
WD repeat domain phosphoinositide-interacting protein 2.
   
 0.983
RAB33B
Ras-related protein Rab-33B.
    
 0.983
GW7_10799
WD repeat domain phosphoinositide-interacting protein 2.
   
 0.837
GW7_07106
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 0.802
Pik3r4
Phosphoinositide 3-kinase regulatory subunit 4.
     
 0.797
Atg7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
     
 0.797
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.