Map3k6 protein (Heterocephalus glaber) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Map3k6

Mitogen-activated protein kinase kinase kinase 6. (1250 aa)

Predicted Functional Partners:

Map2k3

0.973

Txn

0.860

Map2k4

0.789

GW7_17003

0.775

GW7_09586

0.748

GW7_13290

0.681

GW7_09455

0.657

TRAF6

0.653

GW7_02303

0.647

TXN2

0.620

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GW7_02303	Map3k6	G5BPK8	G5AUT4	Thioredoxin domain-containing protein 6.	Mitogen-activated protein kinase kinase kinase 6.	0.647
GW7_02303	TXN2	G5BPK8	G5BAW6	Thioredoxin domain-containing protein 6.	Thioredoxin, mitochondrial.	0.574
GW7_09455	Map3k6	G5B3V6	G5AUT4	Thioredoxin domain-containing protein 3.	Mitogen-activated protein kinase kinase kinase 6.	0.657
GW7_09455	TXN2	G5B3V6	G5BAW6	Thioredoxin domain-containing protein 3.	Thioredoxin, mitochondrial.	0.738
GW7_09586	GW7_17003	G5BEL4	G5C093	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Thioredoxin; Belongs to the thioredoxin family.	0.450
GW7_09586	Map2k3	G5BEL4	G5BKN0	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.835
GW7_09586	Map3k6	G5BEL4	G5AUT4	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 6.	0.748
GW7_09586	TRAF6	G5BEL4	G5B132	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.620
GW7_09586	Txn	G5BEL4	G5C094	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Thioredoxin.	0.473
GW7_13290	Map3k6	G5BUI8	G5AUT4	Dedicator of cytokinesis protein 6; Belongs to the DOCK family.	Mitogen-activated protein kinase kinase kinase 6.	0.681
GW7_17003	GW7_09586	G5C093	G5BEL4	Thioredoxin; Belongs to the thioredoxin family.	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.450
GW7_17003	Map2k3	G5C093	G5BKN0	Thioredoxin; Belongs to the thioredoxin family.	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.450
GW7_17003	Map3k6	G5C093	G5AUT4	Thioredoxin; Belongs to the thioredoxin family.	Mitogen-activated protein kinase kinase kinase 6.	0.775
GW7_17003	TXN2	G5C093	G5BAW6	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin, mitochondrial.	0.664
Map2k3	GW7_09586	G5BKN0	G5BEL4	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.835
Map2k3	GW7_17003	G5BKN0	G5C093	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Thioredoxin; Belongs to the thioredoxin family.	0.450
Map2k3	Map2k4	G5BKN0	G5B2C1	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.914
Map2k3	Map3k6	G5BKN0	G5AUT4	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 6.	0.973
Map2k3	TRAF6	G5BKN0	G5B132	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.616
Map2k3	Txn	G5BKN0	G5C094	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Thioredoxin.	0.490