STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AdnpActivity-dependent neuroprotector homeobox protein. (1111 aa)    
Predicted Functional Partners:
Chd4
Chromodomain-helicase-DNA-binding protein 4.
   
 
 0.842
Trip12
Putative E3 ubiquitin-protein ligase TRIP12.
   
  
 0.727
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 
 0.715
GW7_20868
Nucleosome-remodeling factor subunit BPTF.
   
  
 0.631
Ash1l
Putative histone-lysine N-methyltransferase ASH1L.
   
 
 0.583
GW7_13846
Chromodomain-helicase-DNA-binding protein 3.
   
 
 0.533
GW7_09160
Chromodomain-helicase-DNA-binding protein 5.
   
 
 0.533
CBX1
Chromobox protein-like protein 1.
    
 
 0.528
Insc
Inscuteable-like protein.
      
 0.476
GW7_06816
Autoimmune regulator.
   
 
 0.464
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.