STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mapk8Mitogen-activated protein kinase. (427 aa)    
Predicted Functional Partners:
Map2k4
Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
  
0.994
Mapk8ip1
C-jun-amino-terminal kinase-interacting protein 1.
   
 0.985
DUSP16
Dual specificity protein phosphatase 16.
   
 0.984
MAPK9
Mitogen-activated protein kinase.
  
 
0.984
Tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.979
Nfatc3
Nuclear factor of activated T-cells, cytoplasmic 3.
    
 0.975
Fos
Proto-oncogene protein c-fos.
    
 0.970
Dusp8
Dual specificity protein phosphatase 8.
   
 0.968
Map3k1
Mitogen-activated protein kinase kinase kinase 1.
    
0.965
DUSP10
Dual specificity protein phosphatase 10 isoform b; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
   
 0.964
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.