STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TxkTyrosine-protein kinase. (447 aa)    
Predicted Functional Partners:
Itk
Tyrosine-protein kinase.
  
 
 
0.954
Vav2
Guanine nucleotide exchange factor VAV2.
   
 0.952
Pik3cb
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.
   
 0.920
Pik3r1
Phosphatidylinositol 3-kinase regulatory subunit alpha.
    
 0.918
Lcp2
Lymphocyte cytosolic protein 2.
   
 0.710
GW7_20476
Proto-oncogene vav.
   
 0.653
Grap2
GRB2-related adapter protein 2.
   
0.640
GRB2
Growth factor receptor-bound protein 2 isoform 2.
   
0.593
GW7_17480
Guanine nucleotide exchange factor VAV3.
   
 0.584
GW7_18072
Phosphoinositide phospholipase C.
   
0.580
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.