STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GW7_00215BRISC complex subunit Abro1. (245 aa)    
Predicted Functional Partners:
Babam1
BRCA1-A complex subunit MERIT40.
    
 0.962
Bre
BRCA1-A complex subunit BRE.
    
 0.962
GW7_07849
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
    
 0.946
GW7_15176
Lys-63-specific deubiquitinase BRCC36.
    
 0.913
GW7_06132
Lys-63-specific deubiquitinase BRCC36.
    
 0.913
GW7_15486
BRCA1-A complex subunit RAP80.
    
 0.910
Uimc1
BRCA1-A complex subunit RAP80.
    
 0.910
Bard1
BRCA1-associated RING domain protein 1.
    
 0.902
GW7_12430
Ankyrin repeat domain-containing protein 11.
    
 0.757
ANKRD12
Ankyrin repeat domain-containing protein 12 isoform 1.
    
 0.757
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.