Icos protein (Heterocephalus glaber) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

Icos

Inducible T-cell costimulator. (188 aa)

Predicted Functional Partners:

Icoslg

0.997

Cd40lg

0.981

Pik3r1

0.966

Pik3cb

0.928

Ctla4

0.906

Cd28

0.800

Klrg1

0.796

Klhl6

0.753

Cd2

0.718

GW7_11053

0.708

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd2	Cd28	G5BFJ5	G5C9P3	T-cell surface antigen CD2.	T-cell-specific surface glycoprotein CD28.	0.708
Cd2	Cd40lg	G5BFJ5	G5ANA5	T-cell surface antigen CD2.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.558
Cd2	Ctla4	G5BFJ5	G5BKP2	T-cell surface antigen CD2.	Cytotoxic T-lymphocyte protein 4.	0.466
Cd2	GW7_11053	G5BFJ5	G5B2F1	T-cell surface antigen CD2.	T-lymphocyte activation antigen CD86.	0.536
Cd2	Icos	G5BFJ5	G5BKP1	T-cell surface antigen CD2.	Inducible T-cell costimulator.	0.718
Cd28	Cd2	G5C9P3	G5BFJ5	T-cell-specific surface glycoprotein CD28.	T-cell surface antigen CD2.	0.708
Cd28	Cd40lg	G5C9P3	G5ANA5	T-cell-specific surface glycoprotein CD28.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.750
Cd28	Ctla4	G5C9P3	G5BKP2	T-cell-specific surface glycoprotein CD28.	Cytotoxic T-lymphocyte protein 4.	0.776
Cd28	GW7_11053	G5C9P3	G5B2F1	T-cell-specific surface glycoprotein CD28.	T-lymphocyte activation antigen CD86.	0.954
Cd28	Icos	G5C9P3	G5BKP1	T-cell-specific surface glycoprotein CD28.	Inducible T-cell costimulator.	0.800
Cd28	Icoslg	G5C9P3	G5BG16	T-cell-specific surface glycoprotein CD28.	ICOS ligand.	0.952
Cd28	Klrg1	G5C9P3	G5BPM2	T-cell-specific surface glycoprotein CD28.	Killer cell lectin-like receptor subfamily G member 1.	0.483
Cd28	Pik3cb	G5C9P3	G5AQ99	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.924
Cd28	Pik3r1	G5C9P3	G5C7Q9	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.987
Cd40lg	Cd2	G5ANA5	G5BFJ5	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	T-cell surface antigen CD2.	0.558
Cd40lg	Cd28	G5ANA5	G5C9P3	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	T-cell-specific surface glycoprotein CD28.	0.750
Cd40lg	Ctla4	G5ANA5	G5BKP2	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Cytotoxic T-lymphocyte protein 4.	0.557
Cd40lg	GW7_11053	G5ANA5	G5B2F1	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	T-lymphocyte activation antigen CD86.	0.705
Cd40lg	Icos	G5ANA5	G5BKP1	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Inducible T-cell costimulator.	0.981
Cd40lg	Icoslg	G5ANA5	G5BG16	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	ICOS ligand.	0.671