node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | Atr | G5BXR2 | G5AZ55 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.999 |
ATM | Bard1 | G5BXR2 | G5BHR8 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1-associated RING domain protein 1. | 0.983 |
ATM | Brip1 | G5BXR2 | G5BAX6 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Fanconi anemia group J protein. | 0.735 |
ATM | Cdc45 | G5BXR2 | G5CA14 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | CDC45-related protein. | 0.514 |
ATM | GW7_11013 | G5BXR2 | G5C0I4 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cell cycle checkpoint protein RAD17. | 0.943 |
ATM | Rad1 | G5BXR2 | G5BQ93 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cell cycle checkpoint protein RAD1. | 0.922 |
ATM | Rtel1 | G5BXR2 | G5C8C4 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Regulator of telomere elongation helicase 1. | 0.735 |
ATM | Slf1 | G5BXR2 | G5BU37 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ankyrin repeat domain-containing protein 32. | 0.979 |
ATM | Wrn | G5BXR2 | G5C9Z1 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Werner syndrome ATP-dependent helicase. | 0.993 |
Atr | ATM | G5AZ55 | G5BXR2 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.999 |
Atr | Bard1 | G5AZ55 | G5BHR8 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | BRCA1-associated RING domain protein 1. | 0.880 |
Atr | Brip1 | G5AZ55 | G5BAX6 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Fanconi anemia group J protein. | 0.666 |
Atr | Cdc45 | G5AZ55 | G5CA14 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | CDC45-related protein. | 0.875 |
Atr | GW7_11013 | G5AZ55 | G5C0I4 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Cell cycle checkpoint protein RAD17. | 0.964 |
Atr | Rad1 | G5AZ55 | G5BQ93 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Cell cycle checkpoint protein RAD1. | 0.991 |
Atr | Rtel1 | G5AZ55 | G5C8C4 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Regulator of telomere elongation helicase 1. | 0.666 |
Atr | Slf1 | G5AZ55 | G5BU37 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Ankyrin repeat domain-containing protein 32. | 0.993 |
Atr | Wrn | G5AZ55 | G5C9Z1 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Werner syndrome ATP-dependent helicase. | 0.997 |
Bard1 | ATM | G5BHR8 | G5BXR2 | BRCA1-associated RING domain protein 1. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.983 |
Bard1 | Atr | G5BHR8 | G5AZ55 | BRCA1-associated RING domain protein 1. | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.880 |