STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slf1Ankyrin repeat domain-containing protein 32. (1052 aa)    
Predicted Functional Partners:
Bard1
BRCA1-associated RING domain protein 1.
   
0.994
Atr
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.993
Cdc45
CDC45-related protein.
   
 
 0.990
Wrn
Werner syndrome ATP-dependent helicase.
   
 0.983
PSMD12
26S proteasome non-ATPase regulatory subunit 12 isoform 2.
    
 0.980
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
   
 0.979
GW7_11013
Cell cycle checkpoint protein RAD17.
   
 0.976
Brip1
Fanconi anemia group J protein.
   
 0.975
Rad1
Cell cycle checkpoint protein RAD1.
    
 0.975
Rtel1
Regulator of telomere elongation helicase 1.
   
 0.975
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
Server load: low (26%) [HD]