node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aco2 | Bckdha | G5BPP6 | G5AZS5 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.439 |
Aco2 | DLD | G5BPP6 | G5C2C6 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Dihydrolipoyl dehydrogenase. | 0.745 |
Aco2 | DLST | G5BPP6 | G5C1L8 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.939 |
Aco2 | Ogdh | G5BPP6 | G5BIL1 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 2-oxoglutarate dehydrogenase E1 component, mitochondrial. | 0.920 |
Aco2 | Ogdhl | G5BPP6 | G5AXZ3 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 2-oxoglutarate dehydrogenase E1 component-like, mitochondrial. | 0.920 |
Aco2 | PDHB | G5BPP6 | G5BUK7 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.681 |
Aco2 | SUCLA2 | G5BPP6 | G5BTQ7 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.679 |
Aco2 | SUCLG1 | G5BPP6 | G5BVG8 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.926 |
BCKDHB | Bckdha | G5BGH0 | G5AZS5 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.999 |
BCKDHB | DLD | G5BGH0 | G5C2C6 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | Dihydrolipoyl dehydrogenase. | 0.998 |
BCKDHB | DLST | G5BGH0 | G5C1L8 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.974 |
BCKDHB | Gcdh | G5BGH0 | G5BYW3 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | Glutaryl-CoA dehydrogenase, mitochondrial. | 0.475 |
BCKDHB | Ogdh | G5BGH0 | G5BIL1 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | 2-oxoglutarate dehydrogenase E1 component, mitochondrial. | 0.768 |
BCKDHB | Ogdhl | G5BGH0 | G5AXZ3 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | 2-oxoglutarate dehydrogenase E1 component-like, mitochondrial. | 0.768 |
BCKDHB | PDHB | G5BGH0 | G5BUK7 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.698 |
BCKDHB | SUCLA2 | G5BGH0 | G5BTQ7 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.455 |
BCKDHB | SUCLG1 | G5BGH0 | G5BVG8 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.709 |
Bckdha | Aco2 | G5AZS5 | G5BPP6 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 0.439 |
Bckdha | BCKDHB | G5AZS5 | G5BGH0 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. | 0.999 |
Bckdha | DLD | G5AZS5 | G5C2C6 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Dihydrolipoyl dehydrogenase. | 0.997 |