STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GW7_12697AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (887 aa)    
Predicted Functional Partners:
GW7_18126
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.994
GW7_04579
AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.
   
 0.970
GW7_17237
AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.
   
 0.970
GW7_13987
Intersectin-2.
   
 0.969
GW7_18272
AP complex subunit beta.
   
0.954
GW7_21525
AP complex subunit beta.
   
 0.931
Tgoln2
Trans-Golgi network integral membrane protein 2.
    
 0.924
Ap1b1
AP complex subunit beta.
   
0.915
GW7_16288
Intersectin-1.
    
 0.910
Necap2
Adaptin ear-binding coat-associated protein 2.
    
  0.901
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.