STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (362 aa)    
Predicted Functional Partners:
Polg2
DNA polymerase subunit gamma-2, mitochondrial.
      
 0.569
GW7_18629
DNA2-like helicase.
   
  
 0.559
GW7_20522
G-rich sequence factor 1.
    
 
 0.556
Twnk
Twinkle protein, mitochondrial.
      
 0.556
SELRC1
Sel1 repeat-containing protein 1.
      
 0.552
GW7_02257
Uncharacterized protein.
      
 0.542
MLH3
DNA mismatch repair protein Mlh3 isoform 2.
      
 0.542
GW7_02267
Uncharacterized protein.
      
 0.539
GW7_11605
Coiled-coil domain-containing protein 150.
      
 0.536
Carnmt1
N2227 domain-containing protein.
      
 0.535
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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