STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BpHYR1_047857Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (121 aa)    
Predicted Functional Partners:
BpHYR1_039363
AT-rich interactive domain-containing 4B.
    
 0.946
BpHYR1_048625
Retinoblastoma-binding 5-like protein.
    
 0.893
BpHYR1_037360
Core histone macro-isoform X2.
   
 0.892
BpHYR1_052833
Set1 Ash2 histone methyltransferase complex subunit ASH2.
    
 0.891
BpHYR1_036213
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.873
BpHYR1_036539
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.870
BpHYR1_002598
DNA-directed RNA polymerase II subunit RPB3.
    
 0.866
BpHYR1_041824
Ubiquitin-60S ribosomal L40.
    
 0.864
BpHYR1_023032
Histone H2A; Belongs to the histone H2A family.
   
 0.864
BpHYR1_016508
Histone H2A; Belongs to the histone H2A family.
   
 0.864
Your Current Organism:
Brachionus plicatilis
NCBI taxonomy Id: 10195
Other names: B. plicatilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.