BpHYR1_038308 protein (Brachionus plicatilis)

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BpHYR1_038308

RecQ-mediated genome instability 1. (531 aa)

Predicted Functional Partners:

BpHYR1_047671

0.999

BpHYR1_047678

0.999

BpHYR1_022868

0.995

BpHYR1_024115

0.995

BpHYR1_006932

0.993

BpHYR1_005959

0.989

BpHYR1_025329

0.989

BpHYR1_054654

0.988

BpHYR1_017873

0.988

BpHYR1_017783

0.977

Your Current Organism:

Brachionus plicatilis

NCBI taxonomy Id: 10195
Other names: B. plicatilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BpHYR1_005959	BpHYR1_006932	A0A3M7PKL8	A0A3M7SG86	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Replication A 14 kDa subunit.	0.977
BpHYR1_005959	BpHYR1_017783	A0A3M7PKL8	A0A3M7QU76	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Replication A 32 kDa subunit.	0.950
BpHYR1_005959	BpHYR1_017873	A0A3M7PKL8	A0A3M7RLZ7	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Bloom syndrome-like protein.	0.967
BpHYR1_005959	BpHYR1_022868	A0A3M7PKL8	A0A3M7S981	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.983
BpHYR1_005959	BpHYR1_024115	A0A3M7PKL8	A0A3M7TAA9	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.795
BpHYR1_005959	BpHYR1_038308	A0A3M7PKL8	A0A3M7RYQ1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	RecQ-mediated genome instability 1.	0.989
BpHYR1_005959	BpHYR1_047671	A0A3M7PKL8	A0A3M7T2V9	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Fanconi anemia group M isoform X1.	0.999
BpHYR1_005959	BpHYR1_047678	A0A3M7PKL8	A0A3M7T3F7	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Fanconi anemia group M.	0.999
BpHYR1_005959	BpHYR1_054654	A0A3M7PKL8	A0A3M7PFF7	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Bloom syndrome-like protein.	0.967
BpHYR1_006932	BpHYR1_005959	A0A3M7SG86	A0A3M7PKL8	Replication A 14 kDa subunit.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.977
BpHYR1_006932	BpHYR1_017783	A0A3M7SG86	A0A3M7QU76	Replication A 14 kDa subunit.	Replication A 32 kDa subunit.	0.997
BpHYR1_006932	BpHYR1_017873	A0A3M7SG86	A0A3M7RLZ7	Replication A 14 kDa subunit.	Bloom syndrome-like protein.	0.976
BpHYR1_006932	BpHYR1_022868	A0A3M7SG86	A0A3M7S981	Replication A 14 kDa subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.998
BpHYR1_006932	BpHYR1_024115	A0A3M7SG86	A0A3M7TAA9	Replication A 14 kDa subunit.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.948
BpHYR1_006932	BpHYR1_025329	A0A3M7SG86	A0A3M7QME9	Replication A 14 kDa subunit.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.977
BpHYR1_006932	BpHYR1_038308	A0A3M7SG86	A0A3M7RYQ1	Replication A 14 kDa subunit.	RecQ-mediated genome instability 1.	0.993
BpHYR1_006932	BpHYR1_047671	A0A3M7SG86	A0A3M7T2V9	Replication A 14 kDa subunit.	Fanconi anemia group M isoform X1.	0.954
BpHYR1_006932	BpHYR1_047678	A0A3M7SG86	A0A3M7T3F7	Replication A 14 kDa subunit.	Fanconi anemia group M.	0.954
BpHYR1_006932	BpHYR1_054654	A0A3M7SG86	A0A3M7PFF7	Replication A 14 kDa subunit.	Bloom syndrome-like protein.	0.976
BpHYR1_017783	BpHYR1_005959	A0A3M7QU76	A0A3M7PKL8	Replication A 32 kDa subunit.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.950