STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B3RJ62_TRIADUncharacterized protein. (725 aa)    
Predicted Functional Partners:
B3RYW6_TRIAD
Uncharacterized protein.
   
 0.998
B3S0T1_TRIAD
Uncharacterized protein.
  
 0.969
B3RMJ4_TRIAD
AAA domain-containing protein.
   
 
 0.962
B3RSB2_TRIAD
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.958
B3RQF3_TRIAD
DNA_mis_repair domain-containing protein.
  
 0.908
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 0.907
B3SAF8_TRIAD
ERCC4 domain-containing protein.
   
 0.900
B3RXP3_TRIAD
DUF1767 domain-containing protein.
   
 0.895
B3S3R0_TRIAD
Uncharacterized protein.
   
 0.876
B3SDE2_TRIAD
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
 0.865
Your Current Organism:
Trichoplax adhaerens
NCBI taxonomy Id: 10228
Other names: T. adhaerens
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.