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FEN1 protein (Trichoplax adhaerens) - STRING interaction network
"FEN1" - Flap endonuclease 1 in Trichoplax adhaerens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FEN1Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (377 aa)    
Predicted Functional Partners:
TriadP50695
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (261 aa)
     
 
  0.998
TriadP34086
annotation not available (707 aa)
   
 
  0.985
TriadP63837
annotation not available (904 aa)
   
 
  0.980
TriadP35366
annotation not available (670 aa)
     
 
  0.978
TriadP50536
annotation not available (833 aa)
   
 
  0.972
TriadP30770
annotation not available (752 aa)
   
 
  0.972
TriadP50365
annotation not available (727 aa)
   
 
  0.970
TriadP56718
Uncharacterized protein; Component of the post-replicative DNA mismatch repair system (MMR) (934 aa)
   
 
  0.965
TriadP33687
Uncharacterized protein; Component of the post-replicative DNA mismatch repair system (MMR) (984 aa)
   
 
  0.964
TriadP18979
annotation not available (1050 aa)
     
 
  0.948
Your Current Organism:
Trichoplax adhaerens
NCBI taxonomy Id: 10228
Other names: T. adhaerens, Trichoplax adhaerens
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