STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.984
sdhA
Succinate dehydrogenase flavoprotein subunit.
 
 0.984
sdhB
Succinate dehydrogenase flavoprotein subunit.
  
 0.964
MLP_32570
Malate dehydrogenase; Protein synonym:malic enzyme.
  
 
 0.940
MLP_32680
Malate dehydrogenase; Protein synonym:malic enzyme.
  
 
 0.940
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 0.931
aceB
Malate synthase.
    
 0.925
sdhC
Succinate dehydrogenase cytochrome b subunit.
     
 0.903
MLP_29200
Putative acyltransferase.
   
 0.889
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.861
Your Current Organism:
Microlunatus phosphovorus
NCBI taxonomy Id: 1032480
Other names: M. phosphovorus NM-1, Microlunatus phosphovorus NM-1, Microlunatus phosphovorus str. NM-1, Microlunatus phosphovorus strain NM-1
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