STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hspALow molecular weight heat shock protein; Belongs to the small heat shock protein (HSP20) family. (165 aa)    
Predicted Functional Partners:
clpB
Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
 
 
 0.858
clpA
ATP-binding protease component ClpA protein; Belongs to the ClpA/ClpB family.
 
 
 0.856
amiB
ATP-dependent protease ATP-binding subunit-like protein AmiB.
  
 
 0.832
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.801
ERJ19258.1
Two-component sensor histidine kinase protein.
  
 
 0.757
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.739
hslV
ATP-dependent protease subunit HslV protein; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
   
  
 0.647
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
  
  
 0.633
cbpA
Curved DNA-binding protein.
  
 
 0.578
hslU
ATP-dependent protease ATPase subunit HslU protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
   
  
 0.557
Your Current Organism:
Salinisphaera shabanensis
NCBI taxonomy Id: 1033802
Other names: S. shabanensis E1L3A, Salinisphaera shabanensis E1L3A, Salinisphaera shabanensis str. E1L3A, Salinisphaera shabanensis strain E1L3A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.