sitD protein (Salinisphaera shabanensis) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

sitD

ABC Mn+2-Fe+2 transporter inner membrane subunit SitD protein. (284 aa)

Predicted Functional Partners:

sitB

0.999

sitA

0.998

sitC

0.866

ERJ17439.1

0.627

ERJ18893.1

0.487

ERJ20110.1

0.477

ERJ20422.1

0.466

mntH

0.466

ERJ18816.1

0.448

yhbG

0.430

Your Current Organism:

Salinisphaera shabanensis

NCBI taxonomy Id: 1033802
Other names: S. shabanensis E1L3A, Salinisphaera shabanensis E1L3A, Salinisphaera shabanensis str. E1L3A, Salinisphaera shabanensis strain E1L3A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERJ17439.1	ERJ18816.1	SSPSH_003762	SSPSH_002309	Nitrate reductase 2 alpha subunit protein.	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	0.417
ERJ17439.1	sitA	SSPSH_003762	SSPSH_001803	Nitrate reductase 2 alpha subunit protein.	ABC Mn+2-Fe+2 transporter periplasmic substrate-binding protein SitA; Belongs to the bacterial solute-binding protein 9 family.	0.823
ERJ17439.1	sitB	SSPSH_003762	SSPSH_001804	Nitrate reductase 2 alpha subunit protein.	ABC Mn+2-Fe+2 transporter ATPase subunit SitB protein.	0.816
ERJ17439.1	sitC	SSPSH_003762	SSPSH_001805	Nitrate reductase 2 alpha subunit protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitC protein.	0.627
ERJ17439.1	sitD	SSPSH_003762	SSPSH_001806	Nitrate reductase 2 alpha subunit protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitD protein.	0.627
ERJ18816.1	ERJ17439.1	SSPSH_002309	SSPSH_003762	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	Nitrate reductase 2 alpha subunit protein.	0.417
ERJ18816.1	ERJ18893.1	SSPSH_002309	SSPSH_002186	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	Two-component system chemotaxis family sensor kinase CheA protein.	0.999
ERJ18816.1	sitB	SSPSH_002309	SSPSH_001804	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	ABC Mn+2-Fe+2 transporter ATPase subunit SitB protein.	0.483
ERJ18816.1	sitC	SSPSH_002309	SSPSH_001805	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitC protein.	0.448
ERJ18816.1	sitD	SSPSH_002309	SSPSH_001806	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitD protein.	0.448
ERJ18893.1	ERJ18816.1	SSPSH_002186	SSPSH_002309	Two-component system chemotaxis family sensor kinase CheA protein.	Two-component system OmpR family phosphate regulon sensor histidine kinase PhoR protein.	0.999
ERJ18893.1	ERJ20110.1	SSPSH_002186	SSPSH_000974	Two-component system chemotaxis family sensor kinase CheA protein.	Glutamate transport system ATP-binding protein.	0.568
ERJ18893.1	sitA	SSPSH_002186	SSPSH_001803	Two-component system chemotaxis family sensor kinase CheA protein.	ABC Mn+2-Fe+2 transporter periplasmic substrate-binding protein SitA; Belongs to the bacterial solute-binding protein 9 family.	0.442
ERJ18893.1	sitC	SSPSH_002186	SSPSH_001805	Two-component system chemotaxis family sensor kinase CheA protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitC protein.	0.487
ERJ18893.1	sitD	SSPSH_002186	SSPSH_001806	Two-component system chemotaxis family sensor kinase CheA protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitD protein.	0.487
ERJ20110.1	ERJ18893.1	SSPSH_000974	SSPSH_002186	Glutamate transport system ATP-binding protein.	Two-component system chemotaxis family sensor kinase CheA protein.	0.568
ERJ20110.1	sitC	SSPSH_000974	SSPSH_001805	Glutamate transport system ATP-binding protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitC protein.	0.477
ERJ20110.1	sitD	SSPSH_000974	SSPSH_001806	Glutamate transport system ATP-binding protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitD protein.	0.477
ERJ20110.1	yhbG	SSPSH_000974	SSPSH_000340	Glutamate transport system ATP-binding protein.	ABC transporter ATP-binding protein.	0.480
ERJ20422.1	sitC	SSPSH_000532	SSPSH_001805	Mn2 protein.	ABC Mn+2-Fe+2 transporter inner membrane subunit SitC protein.	0.466

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.872

expected number of edges:

10

PPI enrichment p-value:

0.000353

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055088

Lipid homeostasis

5 of 17

2.61

4.52

2.16e-09

GO:0006654

Phosphatidic acid biosynthetic process

4 of 5

3.05

4.27

1.52e-08

GO:0006629

Lipid metabolic process

11 of 427

1.56

3.39

2.28e-14

GO:0046486

Glycerolipid metabolic process

5 of 184

1.58

1.77

4.23e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042171

Lysophosphatidic acid acyltransferase activity

4 of 4

3.14

4.49

6.26e-09

GO:0052689

Carboxylic ester hydrolase activity

5 of 64

2.04

3.13

1.80e-07

GO:0016788

Hydrolase activity, acting on ester bonds

11 of 505

1.48

3.04

6.98e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13767

Mixed, incl. Acylglycerol metabolic process, and Keratinization

11 of 45

2.53

10.86

1.20e-24

CL:13796

Partial AB-hydrolase lipase domain

6 of 6

3.14

7.5

1.32e-14

CL:13841

Lysophosphatidic acid acyltransferase activity, and Patatin-like phospholipase domain-containing protein

5 of 8

2.94

5.64

3.15e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00100

Steroid biosynthesis

6 of 18

2.67

6.34

4.58e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6809371

Formation of the cornified envelope

6 of 8

3.02

7.08

6.19e-14

MAP-6805567

Keratinization

6 of 8

3.02

7.08

6.19e-14

MAP-1266738

Developmental Biology

6 of 50

2.22

4.53

2.21e-10

MAP-1482839

Acyl chain remodelling of PE

4 of 7

2.9

4.33

9.55e-09

MAP-1483206

Glycerophospholipid biosynthesis

4 of 117

1.68

1.65

0.00019

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0442

Lipid degradation

4 of 14

2.6

3.7

9.75e-08

KW-0378

Hydrolase

5 of 451

1.19

1.06

0.00067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00561

Alpha/beta hydrolase fold

7 of 27

2.56

6.61

5.36e-14

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006693

Partial AB-hydrolase lipase domain

5 of 5

3.14

5.75

2.75e-11

IPR025483

Lipase, eukaryotic

4 of 4

3.14

4.36

1.12e-08

IPR029058

Alpha/Beta hydrolase fold

9 of 244

1.71

3.58

1.40e-11

IPR000073

Alpha/beta hydrolase fold-1

4 of 45

2.09

2.29

2.50e-05

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