STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaBInosine-5'-monophosphate dehydrogenase protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)    
Predicted Functional Partners:
guaA
GMP synthase glutamine-hydrolyzing protein.
 
 0.999
guaA-2
GMP synthase glutamine-hydrolyzing protein; Catalyzes the synthesis of GMP from XMP.
 0.999
purH
Bifunctional purine biosynthesis protein PurH.
 
 
 0.940
purA
Adenylosuccinate synthetase protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.934
ribBA
GTP cyclohydrolase II protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.923
tkt2
Transketolase Carbohydrate transport protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.917
ERJ12431.1
Phosphoribosyl transferase domain protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.897
ERJ13455.1
Two-component system chemotaxis family CheB-CheR fusion protein.
  
 
 0.875
pheT
Phenylalanine--tRNA ligase beta subunit protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
   
  
 0.869
ribH
67-dimethyl-8-ribityllumazine synthase protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.867
Your Current Organism:
Haloplasma contractile
NCBI taxonomy Id: 1033810
Other names: H. contractile SSD-17B, Haloplasma contractile SSD-17B, Haloplasma contractile str. SSD-17B, Haloplasma contractile strain SSD-17B
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