STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GIG_03213COG0006 Xaa-Pro aminopeptidase. (348 aa)    
Predicted Functional Partners:
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.678
rpmG
COG0267 Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.
       0.666
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.635
GIG_00712
COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes.
 
 
 0.633
GIG_03814
NADH oxidase; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases.
    
 0.593
GIG_03203
ABC transporter ATP-binding protein; COG1131 ABC-type multidrug transport system, ATPase component.
   
   0.571
GIG_02045
Type 11 methyltransferase; COG0500 SAM-dependent methyltransferases.
  
 
 0.538
GIG_03223
LacI-type transcription repressor; COG1609 Transcriptional regulators.
  
 
 0.532
GIG_03512
COG0492 Thioredoxin reductase.
    
  0.530
GIG_03208
Hypothetical protein; COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component.
       0.525
Your Current Organism:
Mycoplasma anatis
NCBI taxonomy Id: 1034808
Other names: M. anatis 1340, Mycoplasma anatis 1340, Mycoplasma anatis ATCC 25524
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