AFK61017.1 protein (Advenella kashmirensis WT001)

Network Stats

number of nodes:

number of edges:

average node degree:

avg. local clustering coefficient:

0.722

expected number of edges:

PPI enrichment p-value:

0.233

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002029

Desensitization of G protein-coupled receptor signaling pathway

4 of 9

2.95

3.72

2.35e-07

GO:0002031

G protein-coupled receptor internalization

3 of 6

3.0

2.72

1.60e-05

GO:0031623

Receptor internalization

4 of 49

2.22

2.51

1.60e-05

GO:0010737

Protein kinase A signaling

2 of 23

2.24

0.79

0.0384

GO:0007186

G protein-coupled receptor signaling pathway

6 of 1311

0.97

0.65

0.0106

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

5 of 225

1.65

1.72

0.00013

GO:0047696

Beta-adrenergic receptor kinase activity

2 of 4

3.0

1.31

0.0050

GO:0004703

G protein-coupled receptor kinase activity

2 of 6

2.83

1.31

0.0050

GO:0004691

cAMP-dependent protein kinase activity

2 of 4

3.0

1.31

0.0050

GO:0004679

AMP-activated protein kinase activity

2 of 7

2.76

1.31

0.0050

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

3 of 36

2.23

1.74

0.00061

GO:0042995

Cell projection

8 of 1816

0.95

0.86

0.00026

GO:0120025

Plasma membrane bounded cell projection

6 of 1739

0.84

0.56

0.0139

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29061946

(2015) Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma.

6 of 22

2.74

5.58

4.81e-11

PMID:23908835

(2012) Novel strategies for the treatment of heart failure.

5 of 8

3.1

5.32

3.33e-10

PMID:34663757

(2021) The emerging role of heterodimerisation and interacting proteins in ghrelin receptor function.

5 of 21

2.68

4.33

1.13e-08

PMID:33026079

(2020) Metoprolol exerts a non-class effect against ischaemia-reperfusion injury by abrogating exacerbated inflammation.

4 of 5

3.21

4.17

4.39e-08

PMID:31484312

(2019) The Mechanisms Involved in Morphine Addiction: An Overview.

4 of 5

3.21

4.17

4.39e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37925

Mixed, incl. Beta-adrenergic receptor kinase activity, and G protein-coupled receptor internalization

3 of 10

2.78

1.09e-05

CL:37841

Olfactory transduction, and cAMP-dependent protein kinase inhibitor activity

5 of 124

1.91

2.36

1.09e-05

CL:38018

cAMP, and PKA activation in glucagon signalling

2 of 5

2.91

1.71

0.00099

CL:37928

Beta-adrenergic receptor kinase activity, and G protein-coupled receptor internalization

2 of 5

2.91

1.71

0.00099

CL:18951

G alpha (i) signalling events, and Inward rectifier potassium channel activity

3 of 131

1.67

1.11

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05032

Morphine addiction

8 of 77

2.32

6.92

1.04e-15

cfa04340

Hedgehog signaling pathway

6 of 44

2.44

5.8

2.87e-12

cfa04062

Chemokine signaling pathway

8 of 159

2.01

5.15

1.35e-13

cfa04728

Dopaminergic synapse

7 of 118

2.08

4.99

2.87e-12

cfa04724

Glutamatergic synapse

6 of 95

2.11

4.46

1.53e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-418555

G alpha (s) signalling events

6 of 106

2.06

3.74

8.36e-09

CFA-456926

Thrombin signalling through proteinase activated receptors (PARs)

4 of 30

2.43

3.33

5.57e-07

CFA-111885

Opioid Signalling

4 of 64

2.1

2.58

7.76e-06

CFA-5635838

Activation of SMO

3 of 17

2.55

2.52

2.64e-05

CFA-8856825

Cargo recognition for clathrin-mediated endocytosis

4 of 94

1.93

2.23

2.64e-05

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP1165

G protein signaling pathways

5 of 75

2.13

3.89

6.59e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

3 of 25

2.38

1.81

0.00052

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

4 of 173

1.67

1.54

0.00047

KW-0547

Nucleotide-binding

5 of 1028

0.99

0.68

0.0096

KW-0067

ATP-binding

4 of 770

1.02

0.56

0.0384

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 11

2.56

0.8

0.0394

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

4 of 53

2.18

2.6

9.53e-06

SM01017

Arrestin (or S-antigen), C-terminal domain

2 of 10

2.61

1.36

0.0039

SM00220

Serine/Threonine protein kinases, catalytic domain

4 of 240

1.53

1.24

0.0017

SM00315

Regulator of G protein signalling domain

2 of 31

2.11

0.9

0.0233

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK61017.1	AFK61391.1	TKWG_01795	TKWG_04175	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3520 Uncharacterized protein conserved in bacteria.	0.877
AFK61017.1	AFK61394.1	TKWG_01795	TKWG_04210	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	Lipoprotein; COG3521 Uncharacterized protein conserved in bacteria.	0.841
AFK61017.1	AFK61395.1	TKWG_01795	TKWG_04225	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3455 Uncharacterized protein conserved in bacteria.	0.929
AFK61017.1	AFK64301.1	TKWG_01795	TKWG_23540	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3519 Uncharacterized protein conserved in bacteria.	0.837
AFK61017.1	AFK64302.1	TKWG_01795	TKWG_23545	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3518 Uncharacterized protein conserved in bacteria.	0.859
AFK61017.1	AFK64303.1	TKWG_01795	TKWG_23550	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion.	0.803
AFK61017.1	AFK64304.1	TKWG_01795	TKWG_23555	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3157 Hemolysin-coregulated protein (uncharacterized).	0.885
AFK61017.1	AFK64305.1	TKWG_01795	TKWG_23560	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3517 Uncharacterized protein conserved in bacteria.	0.861
AFK61017.1	AFK64306.1	TKWG_01795	TKWG_23565	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	COG3516 Uncharacterized protein conserved in bacteria.	0.885
AFK61017.1	AFK64307.1	TKWG_01795	TKWG_23570	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	Protein ImpA; COG3515 Uncharacterized protein conserved in bacteria.	0.879
AFK61391.1	AFK61017.1	TKWG_04175	TKWG_01795	COG3520 Uncharacterized protein conserved in bacteria.	VgrG protein; COG3501 Uncharacterized protein conserved in bacteria.	0.877
AFK61391.1	AFK61394.1	TKWG_04175	TKWG_04210	COG3520 Uncharacterized protein conserved in bacteria.	Lipoprotein; COG3521 Uncharacterized protein conserved in bacteria.	0.886
AFK61391.1	AFK61395.1	TKWG_04175	TKWG_04225	COG3520 Uncharacterized protein conserved in bacteria.	COG3455 Uncharacterized protein conserved in bacteria.	0.968
AFK61391.1	AFK64301.1	TKWG_04175	TKWG_23540	COG3520 Uncharacterized protein conserved in bacteria.	COG3519 Uncharacterized protein conserved in bacteria.	0.965
AFK61391.1	AFK64302.1	TKWG_04175	TKWG_23545	COG3520 Uncharacterized protein conserved in bacteria.	COG3518 Uncharacterized protein conserved in bacteria.	0.906
AFK61391.1	AFK64303.1	TKWG_04175	TKWG_23550	COG3520 Uncharacterized protein conserved in bacteria.	COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion.	0.841
AFK61391.1	AFK64304.1	TKWG_04175	TKWG_23555	COG3520 Uncharacterized protein conserved in bacteria.	COG3157 Hemolysin-coregulated protein (uncharacterized).	0.935
AFK61391.1	AFK64305.1	TKWG_04175	TKWG_23560	COG3520 Uncharacterized protein conserved in bacteria.	COG3517 Uncharacterized protein conserved in bacteria.	0.905
AFK61391.1	AFK64306.1	TKWG_04175	TKWG_23565	COG3520 Uncharacterized protein conserved in bacteria.	COG3516 Uncharacterized protein conserved in bacteria.	0.925
AFK61391.1	AFK64307.1	TKWG_04175	TKWG_23570	COG3520 Uncharacterized protein conserved in bacteria.	Protein ImpA; COG3515 Uncharacterized protein conserved in bacteria.	0.968

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