AFK61082.1 protein (Advenella kashmirensis WT001)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:

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[Homology]

Score

AFK61082.1

COG1960 Acyl-CoA dehydrogenases. (788 aa)

Predicted Functional Partners:

AFK61080.1

0.813

AFK61081.1

0.800

AFK64337.1

0.753

AFK63397.1

0.750

AFK63405.1

0.718

AFK61031.1

0.711

AFK62159.1

0.711

AFK61480.1

0.708

AFK61075.1

0.687

AFK63339.1

0.679

Your Current Organism:

Advenella kashmirensis WT001

NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK61031.1	AFK61075.1	TKWG_01905	TKWG_02155	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.572
AFK61031.1	AFK61082.1	TKWG_01905	TKWG_02210	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1960 Acyl-CoA dehydrogenases.	0.711
AFK61031.1	AFK61480.1	TKWG_01905	TKWG_04795	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.738
AFK61031.1	AFK62159.1	TKWG_01905	TKWG_09145	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.629
AFK61031.1	AFK63339.1	TKWG_01905	TKWG_17115	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG2030 Acyl dehydratase.	0.578
AFK61031.1	AFK63397.1	TKWG_01905	TKWG_17460	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1960 Acyl-CoA dehydrogenases.	0.446
AFK61031.1	AFK63405.1	TKWG_01905	TKWG_17500	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1960 Acyl-CoA dehydrogenases.	0.446
AFK61031.1	AFK64337.1	TKWG_01905	TKWG_23730	COG1024 Enoyl-CoA hydratase/carnithine racemase.	Hypothetical protein; COG1960 Acyl-CoA dehydrogenases.	0.707
AFK61075.1	AFK61031.1	TKWG_02155	TKWG_01905	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.572
AFK61075.1	AFK61082.1	TKWG_02155	TKWG_02210	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	COG1960 Acyl-CoA dehydrogenases.	0.687
AFK61075.1	AFK61480.1	TKWG_02155	TKWG_04795	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.564
AFK61075.1	AFK62159.1	TKWG_02155	TKWG_09145	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.777
AFK61075.1	AFK64337.1	TKWG_02155	TKWG_23730	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Hypothetical protein; COG1960 Acyl-CoA dehydrogenases.	0.686
AFK61080.1	AFK61081.1	TKWG_02200	TKWG_02205	Hypothetical protein.	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	0.838
AFK61080.1	AFK61082.1	TKWG_02200	TKWG_02210	Hypothetical protein.	COG1960 Acyl-CoA dehydrogenases.	0.813
AFK61081.1	AFK61080.1	TKWG_02205	TKWG_02200	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	Hypothetical protein.	0.838
AFK61081.1	AFK61082.1	TKWG_02205	TKWG_02210	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	COG1960 Acyl-CoA dehydrogenases.	0.800
AFK61082.1	AFK61031.1	TKWG_02210	TKWG_01905	COG1960 Acyl-CoA dehydrogenases.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.711
AFK61082.1	AFK61075.1	TKWG_02210	TKWG_02155	COG1960 Acyl-CoA dehydrogenases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.687
AFK61082.1	AFK61080.1	TKWG_02210	TKWG_02200	COG1960 Acyl-CoA dehydrogenases.	Hypothetical protein.	0.813

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

8 of 941

1.07

1.08

7.32e-05

GO:0006470

Protein dephosphorylation

3 of 67

1.8

1.07

0.0074

GO:0036211

Protein modification process

7 of 1176

0.92

0.7

0.0034

GO:0006468

Protein phosphorylation

4 of 415

1.13

0.57

0.0437

GO:1901564

Organonitrogen compound metabolic process

8 of 2532

0.64

0.41

0.0241

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017018

Myosin phosphatase activity

3 of 45

1.97

1.16

0.0058

GO:0140096

Catalytic activity, acting on a protein

7 of 1272

0.89

0.64

0.0058

GO:0004672

Protein kinase activity

4 of 415

1.13

0.59

0.0390

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. GDP metabolic process, and Signaling receptor complex adaptor activity

3 of 5

2.92

2.59

1.88e-05

CL:1988

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

4 of 32

2.24

2.42

1.88e-05

CL:1900

Mixed, incl. Serine/threonine-protein kinase, and MAPK cascade

5 of 137

1.71

2.01

2.10e-05

CL:1990

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

3 of 26

2.21

1.84

0.00029

CL:13390

Cyclic nucleotide-dependent protein kinase activity, and PPM-type phosphatase, divalent cation binding

2 of 6

2.67

1.43

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

8 of 394

1.45

2.15

1.07e-07

IPR011009

Protein kinase-like domain superfamily

8 of 431

1.41

2.07

1.08e-07

IPR036457

PPM-type phosphatase-like domain superfamily

3 of 30

2.14

1.45

0.0017

IPR001932

PPM-type phosphatase-like domain

3 of 30

2.14

1.45

0.0017

IPR000222

PPM-type phosphatase, divalent cation binding

2 of 12

2.37

0.84

0.0285

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00331

Sigma factor PP2C-like phosphatases

2 of 22

2.1

0.73

0.0449

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