node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFK61673.1 | AFK61676.1 | TKWG_06070 | TKWG_06085 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.911 |
AFK61673.1 | AFK61678.1 | TKWG_06070 | TKWG_06095 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | Sulfite reductase subunit alpha; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.520 |
AFK61673.1 | AFK61679.1 | TKWG_06070 | TKWG_06100 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.726 |
AFK61673.1 | AFK61680.1 | TKWG_06070 | TKWG_06105 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | Sulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.660 |
AFK61673.1 | AFK61936.1 | TKWG_06070 | TKWG_07595 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | benzoyl-CoA oxygenase, component A; COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB. | 0.458 |
AFK61673.1 | AFK63069.1 | TKWG_06070 | TKWG_15275 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | 0.693 |
AFK61676.1 | AFK61673.1 | TKWG_06085 | TKWG_06070 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | 0.911 |
AFK61676.1 | AFK61677.1 | TKWG_06085 | TKWG_06090 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | 0.642 |
AFK61676.1 | AFK61678.1 | TKWG_06085 | TKWG_06095 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfite reductase subunit alpha; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.716 |
AFK61676.1 | AFK61679.1 | TKWG_06085 | TKWG_06100 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.860 |
AFK61676.1 | AFK61680.1 | TKWG_06085 | TKWG_06105 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.751 |
AFK61676.1 | AFK61936.1 | TKWG_06085 | TKWG_07595 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | benzoyl-CoA oxygenase, component A; COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB. | 0.476 |
AFK61676.1 | AFK63068.1 | TKWG_06085 | TKWG_15270 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.524 |
AFK61676.1 | AFK63069.1 | TKWG_06085 | TKWG_15275 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | 0.783 |
AFK61677.1 | AFK61676.1 | TKWG_06090 | TKWG_06085 | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.642 |
AFK61677.1 | AFK61678.1 | TKWG_06090 | TKWG_06095 | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Sulfite reductase subunit alpha; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.623 |
AFK61677.1 | AFK61679.1 | TKWG_06090 | TKWG_06100 | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.742 |
AFK61677.1 | AFK61680.1 | TKWG_06090 | TKWG_06105 | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Sulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.558 |
AFK61677.1 | AFK61936.1 | TKWG_06090 | TKWG_07595 | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | benzoyl-CoA oxygenase, component A; COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB. | 0.458 |
AFK61677.1 | AFK63069.1 | TKWG_06090 | TKWG_15275 | COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | 0.602 |