AFK62164.1 protein (Advenella kashmirensis WT001)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AFK62164.1

COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (305 aa)

Predicted Functional Partners:

AFK60775.1

0.774

AFK62985.1

0.774

AFK63414.1

0.773

AFK61164.1

0.772

AFK63337.1

0.770

AFK63006.1

0.767

AFK60755.1

0.763

AFK64602.1

0.763

AFK64349.1

0.758

AFK61314.1

0.752

Your Current Organism:

Advenella kashmirensis WT001

NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK60755.1	AFK61314.1	TKWG_00125	TKWG_03665	Regulatory protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.662
AFK60755.1	AFK62164.1	TKWG_00125	TKWG_09180	Regulatory protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.763
AFK60755.1	AFK63414.1	TKWG_00125	TKWG_17565	Regulatory protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.751
AFK60755.1	AFK64349.1	TKWG_00125	TKWG_23810	Regulatory protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.645
AFK60775.1	AFK61314.1	TKWG_00275	TKWG_03665	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.758
AFK60775.1	AFK62164.1	TKWG_00275	TKWG_09180	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.774
AFK60775.1	AFK62985.1	TKWG_00275	TKWG_14685	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.773
AFK60775.1	AFK63006.1	TKWG_00275	TKWG_14810	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.766
AFK60775.1	AFK63337.1	TKWG_00275	TKWG_17105	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.770
AFK60775.1	AFK64349.1	TKWG_00275	TKWG_23810	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.755
AFK61164.1	AFK61314.1	TKWG_02710	TKWG_03665	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.731
AFK61164.1	AFK62164.1	TKWG_02710	TKWG_09180	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.772
AFK61164.1	AFK63414.1	TKWG_02710	TKWG_17565	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.769
AFK61314.1	AFK60755.1	TKWG_03665	TKWG_00125	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	Regulatory protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.662
AFK61314.1	AFK60775.1	TKWG_03665	TKWG_00275	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.758
AFK61314.1	AFK61164.1	TKWG_03665	TKWG_02710	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.731
AFK61314.1	AFK62164.1	TKWG_03665	TKWG_09180	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.752
AFK61314.1	AFK62985.1	TKWG_03665	TKWG_14685	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.726
AFK61314.1	AFK63414.1	TKWG_03665	TKWG_17565	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.736
AFK62164.1	AFK60755.1	TKWG_09180	TKWG_00125	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	Regulatory protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.763

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033353

S-adenosylmethionine cycle

3 of 6

3.32

4.18

3.97e-06

GO:0006730

One-carbon metabolic process

3 of 34

2.56

2.9

0.00012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

3.62

5.1

2.79e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30809531

(2019) ITRAQ-Based Quantitative Proteomics Reveals the Proteome Profiles of Primary Duck Embryo Fibroblast Cells Infected with Duck Tembusu Virus.

3 of 15

2.92

3.43

3.13e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7158

Sulfur amino acid biosynthetic process, and Adenosylhomocysteinase-like

3 of 12

3.02

3.86

8.79e-06

CL:7161

Cysteine biosynthetic process, and Adenosylhomocysteinase-like

2 of 5

3.22

2.46

0.00067

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00270

Cysteine and methionine metabolism

3 of 35

2.55

3.73

7.31e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

3.62

4.82

6.35e-07

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

3.62

4.82

6.35e-07

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

4.82

6.35e-07

IPR000043

Adenosylhomocysteinase-like

3 of 3

3.62

4.82

6.35e-07

IPR036291

NAD(P)-binding domain superfamily

3 of 142

1.94

1.7

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

5.53

7.62e-08

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