node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFK61673.1 | AFK61676.1 | TKWG_06070 | TKWG_06085 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.911 |
AFK61673.1 | AFK62417.1 | TKWG_06070 | TKWG_10895 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | uroporphyrin-III C-methyltransferase; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.905 |
AFK61673.1 | hemC | TKWG_06070 | TKWG_10880 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.985 |
AFK61676.1 | AFK61673.1 | TKWG_06085 | TKWG_06070 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. | 0.911 |
AFK61676.1 | AFK62417.1 | TKWG_06085 | TKWG_10895 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrin-III C-methyltransferase; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.905 |
AFK61676.1 | hemC | TKWG_06085 | TKWG_10880 | uroporphyrin-III C-methyltransferase / precorrin- 2 oxidase / ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.987 |
AFK61706.1 | AFK61714.1 | TKWG_06255 | TKWG_06315 | COG0557 Exoribonuclease R. | MJ0042 family finger-like domain-containing protein. | 0.612 |
AFK61706.1 | AFK62230.1 | TKWG_06255 | TKWG_09585 | COG0557 Exoribonuclease R. | Membrane protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.723 |
AFK61706.1 | AFK62417.1 | TKWG_06255 | TKWG_10895 | COG0557 Exoribonuclease R. | uroporphyrin-III C-methyltransferase; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.649 |
AFK61706.1 | AFK63257.1 | TKWG_06255 | TKWG_16585 | COG0557 Exoribonuclease R. | COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. | 0.611 |
AFK61706.1 | lptA | TKWG_06255 | TKWG_03580 | COG0557 Exoribonuclease R. | Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. | 0.768 |
AFK61714.1 | AFK61706.1 | TKWG_06315 | TKWG_06255 | MJ0042 family finger-like domain-containing protein. | COG0557 Exoribonuclease R. | 0.612 |
AFK61714.1 | AFK62230.1 | TKWG_06315 | TKWG_09585 | MJ0042 family finger-like domain-containing protein. | Membrane protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.602 |
AFK61714.1 | AFK62417.1 | TKWG_06315 | TKWG_10895 | MJ0042 family finger-like domain-containing protein. | uroporphyrin-III C-methyltransferase; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.552 |
AFK61714.1 | AFK62418.1 | TKWG_06315 | TKWG_10900 | MJ0042 family finger-like domain-containing protein. | HemY, N-terminal domain-containing protein; COG3071 Uncharacterized enzyme of heme biosynthesis. | 0.539 |
AFK61714.1 | lptA | TKWG_06315 | TKWG_03580 | MJ0042 family finger-like domain-containing protein. | Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. | 0.657 |
AFK62230.1 | AFK61706.1 | TKWG_09585 | TKWG_06255 | Membrane protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | COG0557 Exoribonuclease R. | 0.723 |
AFK62230.1 | AFK61714.1 | TKWG_09585 | TKWG_06315 | Membrane protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | MJ0042 family finger-like domain-containing protein. | 0.602 |
AFK62230.1 | AFK62417.1 | TKWG_09585 | TKWG_10895 | Membrane protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | uroporphyrin-III C-methyltransferase; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.515 |
AFK62230.1 | AFK63257.1 | TKWG_09585 | TKWG_16585 | Membrane protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. | 0.452 |