AFK62811.1 protein (Advenella kashmirensis WT001)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

AFK62811.1

COG1414 Transcriptional regulator. (223 aa)

Predicted Functional Partners:

AFK62810.1

0.767

AFK61466.1

0.720

AFK60968.1

0.698

AFK61030.1

0.672

AFK63306.1

0.671

AFK60995.1

0.660

AFK64218.1

0.645

AFK64293.1

0.627

AFK62440.1

0.615

AFK62439.1

0.613

Your Current Organism:

Advenella kashmirensis WT001

NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK60968.1	AFK60995.1	TKWG_01500	TKWG_01665	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.691
AFK60968.1	AFK61030.1	TKWG_01500	TKWG_01900	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.673
AFK60968.1	AFK62439.1	TKWG_01500	TKWG_11095	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.657
AFK60968.1	AFK62440.1	TKWG_01500	TKWG_11100	COG1414 Transcriptional regulator.	Transcriptional regulator family protein 34; COG1414 Transcriptional regulator.	0.666
AFK60968.1	AFK62811.1	TKWG_01500	TKWG_13530	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.698
AFK60968.1	AFK63306.1	TKWG_01500	TKWG_16920	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.698
AFK60968.1	AFK64293.1	TKWG_01500	TKWG_23500	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.737
AFK60995.1	AFK60968.1	TKWG_01665	TKWG_01500	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.691
AFK60995.1	AFK61030.1	TKWG_01665	TKWG_01900	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.683
AFK60995.1	AFK61466.1	TKWG_01665	TKWG_04700	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.775
AFK60995.1	AFK62439.1	TKWG_01665	TKWG_11095	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.768
AFK60995.1	AFK62440.1	TKWG_01665	TKWG_11100	COG1414 Transcriptional regulator.	Transcriptional regulator family protein 34; COG1414 Transcriptional regulator.	0.770
AFK60995.1	AFK62811.1	TKWG_01665	TKWG_13530	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.660
AFK60995.1	AFK63306.1	TKWG_01665	TKWG_16920	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.769
AFK60995.1	AFK64218.1	TKWG_01665	TKWG_23070	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.767
AFK60995.1	AFK64293.1	TKWG_01665	TKWG_23500	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.754
AFK61030.1	AFK60968.1	TKWG_01900	TKWG_01500	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.673
AFK61030.1	AFK60995.1	TKWG_01900	TKWG_01665	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.683
AFK61030.1	AFK61466.1	TKWG_01900	TKWG_04700	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.613
AFK61030.1	AFK62439.1	TKWG_01900	TKWG_11095	COG1414 Transcriptional regulator.	COG1414 Transcriptional regulator.	0.599

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.836

expected number of edges:

13

PPI enrichment p-value:

0.0148

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010498

Proteasomal protein catabolic process

11 of 152

2.0

6.44

3.47e-19

GO:0006511

Ubiquitin-dependent protein catabolic process

7 of 230

1.63

2.71

1.69e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004298

Threonine-type endopeptidase activity

2 of 3

2.97

1.23

0.0059

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005839

Proteasome core complex

11 of 14

3.04

14.89

1.04e-29

GO:0019773

Proteasome core complex, alpha-subunit complex

6 of 7

3.08

7.69

4.75e-15

GO:0019774

Proteasome core complex, beta-subunit complex

5 of 7

3.0

6.12

4.21e-12

GO:0005634

Nucleus

11 of 2154

0.85

0.94

2.80e-08

GO:0005737

Cytoplasm

11 of 5000

0.49

0.42

0.00022

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3435

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 29

2.72

12.39

1.87e-26

CL:3467

Proteasome core complex

7 of 10

2.99

8.67

4.03e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 42

2.56

11.56

3.67e-26

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-187577

SCF(Skp2)-mediated degradation of p27/p21

10 of 35

2.6

10.62

2.84e-23

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

10 of 36

2.59

10.56

3.03e-23

MAP-1236975

Antigen processing-Cross presentation

10 of 37

2.58

10.5

3.29e-23

MAP-174178

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

11 of 54

2.45

10.35

2.60e-24

MAP-9755511

KEAP1-NFE2L2 pathway

11 of 57

2.43

10.23

2.60e-24

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005839

Proteasome core complex

11 of 14

3.04

14.83

1.37e-29

GOCC:0019773

Proteasome core complex, alpha-subunit complex

6 of 7

3.08

7.59

7.49e-15

GOCC:0019774

Proteasome core complex, beta-subunit complex

5 of 7

3.0

6.03

6.31e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

9 of 11

3.06

11.94

1.59e-23

KW-0647

Proteasome

8 of 11

3.01

10.36

1.83e-20

KW-0963

Cytoplasm

9 of 122

2.01

5.73

5.51e-16

KW-0539

Nucleus

9 of 297

1.63

3.47

1.05e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00227

Proteasome subunit

11 of 15

3.01

14.56

3.35e-29

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001353

Proteasome, subunit alpha/beta

11 of 15

3.01

14.36

9.30e-29

IPR029055

Nucleophile aminohydrolases, N-terminal

11 of 23

2.82

13.2

1.72e-27

IPR023332

Proteasome alpha-type subunit

6 of 7

3.08

7.17

4.88e-14

IPR000426

Proteasome alpha-subunit, N-terminal domain

6 of 7

3.08

7.17

4.88e-14

IPR023333

Proteasome B-type subunit

5 of 8

2.94

5.51

5.62e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00948

Proteasome subunit A N-terminal signature Add an annotation

6 of 7

3.08

7.43

1.53e-14

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