AFK62993.1 protein (Advenella kashmirensis WT001)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

AFK62993.1

Hypothetical protein. (470 aa)

Predicted Functional Partners:

AFK62990.1

0.896

AFK62988.1

0.866

AFK62989.1

0.854

AFK62992.1

0.845

AFK62994.1

0.838

AFK62987.1

0.793

AFK62991.1

0.655

AFK62986.1

0.647

AFK62995.1

0.425

AFK62996.1

0.425

Your Current Organism:

Advenella kashmirensis WT001

NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK62986.1	AFK62987.1	TKWG_14690	TKWG_14695	Hypothetical protein.	COG2064 Flp pilus assembly protein TadC.	0.949
AFK62986.1	AFK62988.1	TKWG_14690	TKWG_14700	Hypothetical protein.	Type II secretion system protein; COG4965 Flp pilus assembly protein TadB.	0.946
AFK62986.1	AFK62989.1	TKWG_14690	TKWG_14705	Hypothetical protein.	General secretion pathway ATPase; COG4964 Flp pilus assembly protein, secretin CpaC; Belongs to the bacterial secretin family.	0.949
AFK62986.1	AFK62990.1	TKWG_14690	TKWG_14710	Hypothetical protein.	SAF domain protein; COG3745 Flp pilus assembly protein CpaB.	0.937
AFK62986.1	AFK62991.1	TKWG_14690	TKWG_14715	Hypothetical protein.	Hypothetical protein.	0.720
AFK62986.1	AFK62992.1	TKWG_14690	TKWG_14720	Hypothetical protein.	Hypothetical protein.	0.624
AFK62986.1	AFK62993.1	TKWG_14690	TKWG_14725	Hypothetical protein.	Hypothetical protein.	0.647
AFK62986.1	AFK62994.1	TKWG_14690	TKWG_14730	Hypothetical protein.	Integral membrane protein.	0.635
AFK62987.1	AFK62986.1	TKWG_14695	TKWG_14690	COG2064 Flp pilus assembly protein TadC.	Hypothetical protein.	0.949
AFK62987.1	AFK62988.1	TKWG_14695	TKWG_14700	COG2064 Flp pilus assembly protein TadC.	Type II secretion system protein; COG4965 Flp pilus assembly protein TadB.	0.995
AFK62987.1	AFK62989.1	TKWG_14695	TKWG_14705	COG2064 Flp pilus assembly protein TadC.	General secretion pathway ATPase; COG4964 Flp pilus assembly protein, secretin CpaC; Belongs to the bacterial secretin family.	0.988
AFK62987.1	AFK62990.1	TKWG_14695	TKWG_14710	COG2064 Flp pilus assembly protein TadC.	SAF domain protein; COG3745 Flp pilus assembly protein CpaB.	0.985
AFK62987.1	AFK62991.1	TKWG_14695	TKWG_14715	COG2064 Flp pilus assembly protein TadC.	Hypothetical protein.	0.720
AFK62987.1	AFK62992.1	TKWG_14695	TKWG_14720	COG2064 Flp pilus assembly protein TadC.	Hypothetical protein.	0.629
AFK62987.1	AFK62993.1	TKWG_14695	TKWG_14725	COG2064 Flp pilus assembly protein TadC.	Hypothetical protein.	0.793
AFK62987.1	AFK62994.1	TKWG_14695	TKWG_14730	COG2064 Flp pilus assembly protein TadC.	Integral membrane protein.	0.639
AFK62988.1	AFK62986.1	TKWG_14700	TKWG_14690	Type II secretion system protein; COG4965 Flp pilus assembly protein TadB.	Hypothetical protein.	0.946
AFK62988.1	AFK62987.1	TKWG_14700	TKWG_14695	Type II secretion system protein; COG4965 Flp pilus assembly protein TadB.	COG2064 Flp pilus assembly protein TadC.	0.995
AFK62988.1	AFK62989.1	TKWG_14700	TKWG_14705	Type II secretion system protein; COG4965 Flp pilus assembly protein TadB.	General secretion pathway ATPase; COG4964 Flp pilus assembly protein, secretin CpaC; Belongs to the bacterial secretin family.	0.990
AFK62988.1	AFK62990.1	TKWG_14700	TKWG_14710	Type II secretion system protein; COG4965 Flp pilus assembly protein TadB.	SAF domain protein; COG3745 Flp pilus assembly protein CpaB.	0.989

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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