node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFK61303.1 | AFK61304.1 | TKWG_03590 | TKWG_03595 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.998 |
AFK61303.1 | AFK61412.1 | TKWG_03590 | TKWG_04365 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.843 |
AFK61303.1 | AFK63037.1 | TKWG_03590 | TKWG_15040 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | 3-deoxy-manno-octulosonate cytidylyltransferase; COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase; Belongs to the KdsB family. | 0.999 |
AFK61303.1 | AFK63154.1 | TKWG_03590 | TKWG_15895 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | 2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. | 0.996 |
AFK61303.1 | lpxA | TKWG_03590 | TKWG_11655 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.877 |
AFK61303.1 | lpxB | TKWG_03590 | TKWG_11660 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.900 |
AFK61303.1 | lpxC | TKWG_03590 | TKWG_18630 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.897 |
AFK61303.1 | lpxD | TKWG_03590 | TKWG_11640 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.901 |
AFK61303.1 | lpxK | TKWG_03590 | TKWG_15030 | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.881 |
AFK61304.1 | AFK61303.1 | TKWG_03595 | TKWG_03590 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | 0.998 |
AFK61304.1 | AFK61412.1 | TKWG_03595 | TKWG_04365 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.916 |
AFK61304.1 | AFK63037.1 | TKWG_03595 | TKWG_15040 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | 3-deoxy-manno-octulosonate cytidylyltransferase; COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase; Belongs to the KdsB family. | 0.969 |
AFK61304.1 | AFK63154.1 | TKWG_03595 | TKWG_15895 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | 2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. | 0.990 |
AFK61304.1 | lpxA | TKWG_03595 | TKWG_11655 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.938 |
AFK61304.1 | lpxB | TKWG_03595 | TKWG_11660 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.968 |
AFK61304.1 | lpxC | TKWG_03595 | TKWG_18630 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.955 |
AFK61304.1 | lpxD | TKWG_03595 | TKWG_11640 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.968 |
AFK61304.1 | lpxK | TKWG_03595 | TKWG_15030 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.967 |
AFK61304.1 | pyrG | TKWG_03595 | TKWG_15905 | Arabinose 5-phosphate isomerase; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.449 |
AFK61412.1 | AFK61303.1 | TKWG_04365 | TKWG_03590 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Hydrolase; COG1778 Low specificity phosphatase (HAD superfamily). | 0.843 |