AFK63932.1 protein (Advenella kashmirensis WT001)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFK63932.1

COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain. (268 aa)

Predicted Functional Partners:

AFK61561.1

0.829

AFK62725.1

0.828

AFK62724.1

0.824

AFK61562.1

0.822

AFK61464.1

0.727

AFK61563.1

0.727

AFK64233.1

0.717

AFK61576.1

0.713

AFK61901.1

0.709

AFK61577.1

0.705

Your Current Organism:

Advenella kashmirensis WT001

NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK61464.1	AFK61561.1	TKWG_04690	TKWG_05310	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.478
AFK61464.1	AFK61562.1	TKWG_04690	TKWG_05315	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.498
AFK61464.1	AFK61563.1	TKWG_04690	TKWG_05320	COG0765 ABC-type amino acid transport system, permease component.	COG1126 ABC-type polar amino acid transport system, ATPase component.	0.892
AFK61464.1	AFK61576.1	TKWG_04690	TKWG_05440	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.473
AFK61464.1	AFK61577.1	TKWG_04690	TKWG_05445	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.609
AFK61464.1	AFK61901.1	TKWG_04690	TKWG_07410	COG0765 ABC-type amino acid transport system, permease component.	Polar amino acid ABC transporter inner membrane subunit; COG0765 ABC-type amino acid transport system, permease component.	0.460
AFK61464.1	AFK62724.1	TKWG_04690	TKWG_12970	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.511
AFK61464.1	AFK62725.1	TKWG_04690	TKWG_12975	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.500
AFK61464.1	AFK63932.1	TKWG_04690	TKWG_21105	COG0765 ABC-type amino acid transport system, permease component.	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain.	0.727
AFK61464.1	AFK64233.1	TKWG_04690	TKWG_23145	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.504
AFK61561.1	AFK61464.1	TKWG_05310	TKWG_04690	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.478
AFK61561.1	AFK61562.1	TKWG_05310	TKWG_05315	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.973
AFK61561.1	AFK61563.1	TKWG_05310	TKWG_05320	COG0765 ABC-type amino acid transport system, permease component.	COG1126 ABC-type polar amino acid transport system, ATPase component.	0.995
AFK61561.1	AFK61576.1	TKWG_05310	TKWG_05440	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.505
AFK61561.1	AFK61577.1	TKWG_05310	TKWG_05445	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.634
AFK61561.1	AFK61901.1	TKWG_05310	TKWG_07410	COG0765 ABC-type amino acid transport system, permease component.	Polar amino acid ABC transporter inner membrane subunit; COG0765 ABC-type amino acid transport system, permease component.	0.518
AFK61561.1	AFK62724.1	TKWG_05310	TKWG_12970	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.526
AFK61561.1	AFK63932.1	TKWG_05310	TKWG_21105	COG0765 ABC-type amino acid transport system, permease component.	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain.	0.829
AFK61561.1	AFK64233.1	TKWG_05310	TKWG_23145	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.523
AFK61562.1	AFK61464.1	TKWG_05315	TKWG_04690	COG0765 ABC-type amino acid transport system, permease component.	COG0765 ABC-type amino acid transport system, permease component.	0.498

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

10

average node degree:

1.82

avg. local clustering coefficient:

0.909

expected number of edges:

11

PPI enrichment p-value:

0.62

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030177

Positive regulation of Wnt signaling pathway

6 of 96

2.06

3.43

3.52e-08

GO:0030111

Regulation of Wnt signaling pathway

8 of 248

1.77

3.35

1.03e-09

GO:0016055

Wnt signaling pathway

5 of 182

1.7

1.77

0.00010

GO:2001013

Epithelial cell proliferation involved in renal tubule morphogenesis

2 of 4

2.96

1.33

0.0040

GO:0060828

Regulation of canonical Wnt signaling pathway

4 of 190

1.59

1.15

0.0031

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016500

Protein-hormone receptor activity

3 of 19

2.46

1.75

0.00055

GO:0008201

Heparin binding

4 of 129

1.76

1.45

0.00086

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

7 of 1991

0.81

0.47

0.0325

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27104524

(2016) Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles.

9 of 37

2.65

8.72

2.25e-18

PMID:29416699

(2018) LGR5 and LGR6 in stem cell biology and ovarian cancer.

7 of 16

2.9

7.43

8.53e-15

PMID:22982762

(2012) The R-spondin family of proteins: emerging regulators of WNT signaling.

7 of 53

2.38

5.37

8.90e-12

PMID:25276837

(2014) Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wntbeta-catenin signaling pathway.

5 of 25

2.56

3.91

3.36e-08

PMID:38255775

(2024) Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm.

5 of 45

2.31

3.24

3.98e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15139

Mixed, incl. Regulation of FZD by ubiquitination, and WSC domain

9 of 14

3.07

11.51

1.31e-22

CL:15143

Epithelial cell proliferation involved in renal tubule morphogenesis, and Furin-like repeat

5 of 5

3.26

6.25

3.73e-12

CL:20511

Teneurin Intracellular Region, and Latrophilin Cytoplasmic C-terminal region

2 of 6

2.79

1.24

0.0057

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04310

Wnt signaling pathway

8 of 135

2.04

5.08

2.77e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-4641263

Regulation of FZD by ubiquitination

7 of 15

2.93

8.16

3.29e-16

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000305

Crypt

2 of 9

2.61

0.84

0.0302

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0732

Signal

7 of 2280

0.75

0.47

0.0212

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

2 of 3

3.09

1.22

0.0062

PF02140

Galactose binding lectin domain

2 of 5

2.87

1.21

0.0065

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

2 of 10

2.56

1.02

0.0136

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00261

Furin-like repeats

4 of 16

2.66

3.59

1.85e-07

SM00209

Thrombospondin type 1 repeats

4 of 61

2.08

2.41

1.28e-05

SM00284

Olfactomedin-like domains

2 of 14

2.42

1.12

0.0087

SM00008

Domain present in hormone receptors

2 of 23

2.2

1.01

0.0130

SM00369

Leucine-rich repeats, typical (most populated) subfamily

3 of 122

1.65

1.0

0.0087

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About