AFK63993.1 protein (Advenella kashmirensis WT001)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

AFK63993.1

COG1454 Alcohol dehydrogenase, class IV. (354 aa)

Predicted Functional Partners:

AFK64040.1

0.925

AFK61539.1

0.914

AFK61918.1

0.914

AFK62825.1

0.913

AFK63331.1

0.912

AFK63389.1

0.912

AFK63390.1

0.910

AFK61752.1

0.901

AFK63994.1

0.773

AFK64118.1

0.659

Your Current Organism:

Advenella kashmirensis WT001

NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK61539.1	AFK61918.1	TKWG_05175	TKWG_07495	COG0412 Dienelactone hydrolase and related enzymes.	COG0412 Dienelactone hydrolase and related enzymes.	0.924
AFK61539.1	AFK63993.1	TKWG_05175	TKWG_21530	COG0412 Dienelactone hydrolase and related enzymes.	COG1454 Alcohol dehydrogenase, class IV.	0.914
AFK61539.1	AFK64040.1	TKWG_05175	TKWG_21815	COG0412 Dienelactone hydrolase and related enzymes.	COG1454 Alcohol dehydrogenase, class IV.	0.914
AFK61752.1	AFK62825.1	TKWG_06565	TKWG_13620	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.921
AFK61752.1	AFK63331.1	TKWG_06565	TKWG_17075	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.905
AFK61752.1	AFK63389.1	TKWG_06565	TKWG_17420	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.905
AFK61752.1	AFK63390.1	TKWG_06565	TKWG_17425	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit.	0.908
AFK61752.1	AFK63993.1	TKWG_06565	TKWG_21530	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG1454 Alcohol dehydrogenase, class IV.	0.901
AFK61752.1	AFK64040.1	TKWG_06565	TKWG_21815	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG1454 Alcohol dehydrogenase, class IV.	0.901
AFK61918.1	AFK61539.1	TKWG_07495	TKWG_05175	COG0412 Dienelactone hydrolase and related enzymes.	COG0412 Dienelactone hydrolase and related enzymes.	0.924
AFK61918.1	AFK63993.1	TKWG_07495	TKWG_21530	COG0412 Dienelactone hydrolase and related enzymes.	COG1454 Alcohol dehydrogenase, class IV.	0.914
AFK61918.1	AFK64040.1	TKWG_07495	TKWG_21815	COG0412 Dienelactone hydrolase and related enzymes.	COG1454 Alcohol dehydrogenase, class IV.	0.914
AFK62825.1	AFK61752.1	TKWG_13620	TKWG_06565	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.921
AFK62825.1	AFK63331.1	TKWG_13620	TKWG_17075	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.905
AFK62825.1	AFK63389.1	TKWG_13620	TKWG_17420	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.917
AFK62825.1	AFK63390.1	TKWG_13620	TKWG_17425	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit.	0.912
AFK62825.1	AFK63993.1	TKWG_13620	TKWG_21530	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG1454 Alcohol dehydrogenase, class IV.	0.913
AFK62825.1	AFK64040.1	TKWG_13620	TKWG_21815	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	COG1454 Alcohol dehydrogenase, class IV.	0.901
AFK63331.1	AFK61752.1	TKWG_17075	TKWG_06565	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	Beta-ketoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.905
AFK63331.1	AFK62825.1	TKWG_17075	TKWG_13620	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.905

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.867

expected number of edges:

13

PPI enrichment p-value:

0.000105

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

10 of 19

2.18

6.96

9.15e-18

GO:0032787

Monocarboxylic acid metabolic process

11 of 93

1.54

3.35

8.03e-15

GO:0071616

acyl-CoA biosynthetic process

3 of 9

1.99

1.69

0.00042

GO:2001295

malonyl-CoA biosynthetic process

2 of 3

2.29

1.29

0.0039

GO:0090407

Organophosphate biosynthetic process

6 of 121

1.16

1.17

9.69e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

5 of 9

2.21

3.27

2.20e-07

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

7 of 62

1.51

2.23

2.20e-07

GO:0003989

acetyl-CoA carboxylase activity

3 of 4

2.34

1.98

0.00018

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 2

2.46

1.23

0.0054

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 3

2.29

1.13

0.0080

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

3 of 4

2.34

2.03

0.00014

GO:1902494

Catalytic complex

4 of 76

1.18

0.9

0.0035

GO:0005737

Cytoplasm

11 of 938

0.53

0.46

0.00014

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36584052

(2022) The inside scoop: Comparative genomics of two intranuclear bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella aquae.

5 of 114

1.1

1.07

0.00015

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1307

Fatty acid biosynthesis, and Phosphopantetheine

9 of 13

2.3

6.98

1.93e-16

CL:1182

Carbon metabolism, and Fatty acid metabolic process

10 of 86

1.53

3.1

8.98e-13

CL:1311

Phosphopantetheine, and Fatty acid synthase activity

3 of 5

2.24

2.06

0.00011

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

8 of 16

2.16

5.7

5.23e-14

map01212

Fatty acid metabolism

8 of 26

1.95

4.7

6.40e-13

map00620

Pyruvate metabolism

4 of 38

1.48

0.00019

map00640

Propanoate metabolism

3 of 23

1.58

1.27

0.0015

map00780

Biotin metabolism

3 of 26

1.52

1.21

0.0018

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

3 of 4

2.34

2.03

0.00014

GOCC:0005737

Cytoplasm

11 of 752

0.63

0.56

3.48e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0444

Lipid biosynthesis

9 of 24

2.04

5.59

4.52e-15

KW-0275

Fatty acid biosynthesis

7 of 12

2.23

5.35

1.67e-12

KW-0012

Acyltransferase

5 of 41

1.55

1.92

8.82e-06

KW-0963

Cytoplasm

6 of 226

0.89

0.71

0.0016

KW-0808

Transferase

7 of 407

0.7

0.52

0.0035

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01039

Carboxyl transferase domain

2 of 3

2.29

0.73

0.0453

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