STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFK64119.1methylated-DNA-(protein)-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (164 aa)    
Predicted Functional Partners:
AFK62564.1
Base excision DNA repair protein; COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase.
 
  
 0.921
lpxB
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
      0.839
AFK64528.1
COG2818 3-methyladenine DNA glycosylase.
   
 0.749
AFK61377.1
COG3663 G:T/U mismatch-specific DNA glycosylase.
 
  
 0.662
AFK63712.1
Hypothetical protein; COG2169 Adenosine deaminase.
 
  
 0.553
AFK63322.1
COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase.
 
  
 0.469
AFK63500.1
AraC family transcriptional regulator; COG2169 Adenosine deaminase.
 
  
0.446
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
   
 0.408
AFK64118.1
COG3508 Homogentisate 1,2-dioxygenase.
       0.404
AFK63427.1
Recombination factor protein RarA; COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase.
 
   
 0.402
Your Current Organism:
Advenella kashmirensis WT001
NCBI taxonomy Id: 1036672
Other names: A. kashmirensis WT001, Advenella kashmirensis str. WT001, Advenella kashmirensis strain WT001, Tetrathiobacter kashmirensis WT001
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.