alr1377 protein (Nostoc sp. PCC7120) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

alr1377

ORF_ID:alr1377; unknown protein. (376 aa)

Predicted Functional Partners:

alr1376

0.946

alr1378

0.916

alr1379

0.768

all0854

0.741

asr2939

0.677

all3180

0.666

all0858

0.651

alr1925

0.635

all3010

0.630

all4929

0.621

Your Current Organism:

Nostoc sp. PCC7120

NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
all0854	all3010	gene:10492867	gene:10495046	ORF_ID:all0854; unknown protein.	ORF_ID:all3010; unknown protein.	0.699
all0854	all3180	gene:10492867	gene:10495217	ORF_ID:all0854; unknown protein.	ORF_ID:all3180; similar to adenylate cyclase.	0.552
all0854	alr1376	gene:10492867	gene:10493391	ORF_ID:all0854; unknown protein.	ORF_ID:alr1376; unknown protein.	0.670
all0854	alr1377	gene:10492867	gene:10493392	ORF_ID:all0854; unknown protein.	ORF_ID:alr1377; unknown protein.	0.741
all0854	alr1378	gene:10492867	gene:10493393	ORF_ID:all0854; unknown protein.	ORF_ID:alr1378; hypothetical protein.	0.605
all0854	alr1379	gene:10492867	gene:10493394	ORF_ID:all0854; unknown protein.	ORF_ID:alr1379; unknown protein.	0.582
all0854	asr2939	gene:10492867	gene:10494975	ORF_ID:all0854; unknown protein.	ORF_ID:asr2939; unknown protein.	0.629
all0858	all3010	gene:10492871	gene:10495046	ORF_ID:all0858; hypothetical protein.	ORF_ID:all3010; unknown protein.	0.726
all0858	all4929	gene:10492871	gene:10496984	ORF_ID:all0858; hypothetical protein.	ORF_ID:all4929; unknown protein.	0.474
all0858	alr1376	gene:10492871	gene:10493391	ORF_ID:all0858; hypothetical protein.	ORF_ID:alr1376; unknown protein.	0.517
all0858	alr1377	gene:10492871	gene:10493392	ORF_ID:all0858; hypothetical protein.	ORF_ID:alr1377; unknown protein.	0.651
all0858	alr1378	gene:10492871	gene:10493393	ORF_ID:all0858; hypothetical protein.	ORF_ID:alr1378; hypothetical protein.	0.499
all0858	alr1925	gene:10492871	gene:10493944	ORF_ID:all0858; hypothetical protein.	Peptidylprolyl isomerase; ORF_ID:alr1925; unknown protein.	0.556
all3010	all0854	gene:10495046	gene:10492867	ORF_ID:all3010; unknown protein.	ORF_ID:all0854; unknown protein.	0.699
all3010	all0858	gene:10495046	gene:10492871	ORF_ID:all3010; unknown protein.	ORF_ID:all0858; hypothetical protein.	0.726
all3010	all3180	gene:10495046	gene:10495217	ORF_ID:all3010; unknown protein.	ORF_ID:all3180; similar to adenylate cyclase.	0.545
all3010	alr1376	gene:10495046	gene:10493391	ORF_ID:all3010; unknown protein.	ORF_ID:alr1376; unknown protein.	0.669
all3010	alr1377	gene:10495046	gene:10493392	ORF_ID:all3010; unknown protein.	ORF_ID:alr1377; unknown protein.	0.630
all3010	alr1378	gene:10495046	gene:10493393	ORF_ID:all3010; unknown protein.	ORF_ID:alr1378; hypothetical protein.	0.562
all3010	alr1925	gene:10495046	gene:10493944	ORF_ID:all3010; unknown protein.	Peptidylprolyl isomerase; ORF_ID:alr1925; unknown protein.	0.444

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.798

expected number of edges:

53

PPI enrichment p-value:

0.935

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

9 of 23

1.85

4.28

1.16e-12

GO:0006412

Translation

11 of 96

1.31

2.28

1.68e-12

GO:0006426

glycyl-tRNA aminoacylation

2 of 2

2.25

1.28

0.0040

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

9 of 24

1.83

4.24

8.42e-13

GO:0002161

aminoacyl-tRNA editing activity

3 of 5

2.03

1.82

0.00024

GO:0000049

tRNA binding

4 of 25

1.46

1.39

0.00033

GO:0004820

glycine-tRNA ligase activity

2 of 2

2.25

1.31

0.0035

GO:0005524

ATP binding

9 of 268

0.78

0.72

5.70e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

11 of 803

0.39

0.31

0.0055

GO:0005737

Cytoplasm

10 of 721

0.4

0.3

0.0168

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:266

Aminoacyl-tRNA synthetase

5 of 18

1.7

2.04

1.50e-05

CL:270

Aminoacyl-tRNA synthetase, class Ia, and glutamyl-tRNA aminoacylation

3 of 6

1.95

1.56

0.00077

CL:62

Translation, and Protein export

8 of 120

1.08

1.16

1.50e-05

CL:720

glycyl-tRNA aminoacylation, and Serine/threonine-protein kinase

2 of 5

1.86

0.78

0.0319

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

9 of 30

1.73

3.88

8.62e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009345

glycine-tRNA ligase complex

2 of 2

2.25

0.8

0.0332

GOCC:0005737

Cytoplasm

9 of 520

0.49

0.32

0.0332

GOCC:0005622

Intracellular

10 of 770

0.37

0.26

0.0401

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

9 of 22

1.87

4.55

1.46e-13

KW-0648

Protein biosynthesis

9 of 37

1.64

3.43

3.93e-12

KW-0820

tRNA-binding

3 of 16

1.53

1.14

0.0029

KW-0963

Cytoplasm

9 of 184

0.94

1.03

1.31e-06

KW-0067

ATP-binding

9 of 184

0.94

1.03

1.31e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 4

2.13

1.5

0.0013

PF08264

Anticodon-binding domain of tRNA ligase

3 of 4

2.13

1.5

0.0013

PF03129

Anticodon binding domain

2 of 3

2.08

0.83

0.0277

PF00587

tRNA synthetase class II core domain (G, H, P, S and T)

2 of 4

1.95

0.8

0.0311

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

5 of 13

1.84

2.23

1.18e-05

IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

3 of 3

2.25

1.59

0.00099

IPR013155

Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding

3 of 4

2.13

1.54

0.0011

IPR002300

Aminoacyl-tRNA synthetase, class Ia

3 of 4

2.13

1.54

0.0011

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

1.95

1.42

0.0016

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 2

2.25

0.99

0.0148

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