Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EP300Histone acetyltransferase p300 isoform X1. (2463 aa)    
Predicted Functional Partners:
CREBBP
CREB-binding protein isoform X1.
  
0.999
TP53
Cellular tumor antigen p53.
    
 0.998
CREB1
Cyclic AMP-responsive element-binding protein 1.
    
 0.997
SP1
Transcription factor Sp1 isoform X1.
   
 0.997
KAT2B
Lysine acetyltransferase 2B.
    
 0.996
KAT2A
Histone acetyltransferase KAT2A.
    
 0.996
MAML1
Mastermind-like protein 1.
   
 0.994
STAT3
Signal transducer and activator of transcription 3.
    
 0.991
ESR1
Estrogen receptor isoform X1.
    
 0.987
RBPJ
Recombining binding protein suppressor of hairless isoform X1.
    
 0.983
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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