Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF8E3 ubiquitin-protein ligase RNF8 isoform X1. (572 aa)    
Predicted Functional Partners:
UBE2N
Ubiquitin-conjugating enzyme E2 N isoform X1.
   
 0.985
RNF168
E3 ubiquitin-protein ligase RNF168 isoform X1.
     
 0.942
TP53BP1
Tumor suppressor p53-binding protein 1.
    
 0.925
PCNA
Proliferating cell nuclear antigen isoform X1.
   
 
 0.918
UBC
Polyubiquitin-C.
   
 0.917
HERC2
E3 ubiquitin-protein ligase HERC2 isoform X1.
   
 0.891
HERC1
LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1.
   
 0.891
NBN
Nibrin isoform X1.
    
 0.888
WRAP53
Telomerase Cajal body protein 1.
    
 
 0.866
RNF169
E3 ubiquitin-protein ligase RNF169.
     
 0.858
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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