STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase 2-binding protein 1 isoform X1. (1494 aa)    
Predicted Functional Partners:
CDC45
Cell division control protein 45 homolog.
   
 0.999
BRCA1
Breast cancer type 1 susceptibility protein.
   
 0.997
BARD1
BRCA1-associated RING domain protein 1.
   
 0.996
MCM5
DNA replication licensing factor MCM5.
   
 0.995
TP53BP1
Tumor suppressor p53-binding protein 1.
    
 
 0.995
MCM3
DNA replication licensing factor MCM3.
   
 0.992
WRN
Werner syndrome ATP-dependent helicase isoform X1.
   
 0.987
RAD9B
RAD9 checkpoint clamp component B.
    
 0.960
RAD9A
Cell cycle checkpoint control protein RAD9A isoform X1.
    
 0.960
GINS1
DNA replication complex GINS protein PSF1.
   
 0.957
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.