Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ERBB4Receptor tyrosine-protein kinase erbB-4. (1233 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-binding protein 2.
    
 0.987
NRG1
Pro-neuregulin-1, membrane-bound isoform isoform X1.
    
 0.976
NRG2
Pro-neuregulin-2, membrane-bound isoform.
    
 0.976
SHC3
SHC-transforming protein 3 isoform X1.
    
 0.970
SHC1
LOW QUALITY PROTEIN: SHC-transforming protein 1.
    
 0.970
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1.
    
 0.967
LOC110082359
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like.
    
 0.967
HBEGF
Proheparin-binding EGF-like growth factor.
    
 0.967
PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.
    
 0.966
EREG
Proepiregulin isoform X1.
    
 0.965
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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