Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MCPH1Microcephalin 1. (687 aa)    
Predicted Functional Partners:
ASPM
Abnormal spindle-like microcephaly-associated protein.
   
 
 0.909
RAD51
DNA repair protein RAD51 homolog 1.
   
 0.889
WRN
Werner syndrome ATP-dependent helicase isoform X1.
   
 0.885
E2F1
Transcription factor E2F1 isoform X1.
    
 0.869
BRCA2
Breast cancer type 2 susceptibility protein.
   
 0.866
SLF1
SMC5-SMC6 complex localization factor protein 1 isoform X1.
   
 0.827
SET
Template-activating factor I.
     
 0.812
LOC110083527
LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR-like.
   
 0.761
CLSPN
Claspin.
   
 0.757
TOPBP1
DNA topoisomerase 2-binding protein 1 isoform X1.
   
 0.749
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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