Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF11E3 ubiquitin-protein ligase RNF11. (154 aa)    
Predicted Functional Partners:
ITCH
E3 ubiquitin-protein ligase Itchy homolog isoform X1.
    
 0.968
SMURF2
E3 ubiquitin-protein ligase SMURF2.
    
 0.967
UBE2N
Ubiquitin-conjugating enzyme E2 N isoform X1.
   
 0.942
WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1.
    
 0.921
TNFAIP3
Tumor necrosis factor alpha-induced protein 3 isoform X1.
   
 
 0.902
RPS27A
Ribosomal protein S27a.
    
 0.874
TAX1BP1
Tax1 binding protein 1.
   
 
 0.868
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.832
NEDD4L
E3 ubiquitin-protein ligase NEDD4-like isoform X1.
    
 0.766
NEDD4
E3 ubiquitin-protein ligase NEDD4.
    
 0.766
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.