Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SPG11Spatacsin isoform X1. (2405 aa)    
Predicted Functional Partners:
AP5Z1
AP-5 complex subunit zeta-1.
    
 
 0.973
ZFYVE26-2
Zinc finger FYVE domain-containing protein 26.
   
 
 0.961
ZFYVE26
Zinc finger FYVE-type containing 26.
   
 
 0.961
AP5M1
AP-5 complex subunit mu-1.
    
 
 0.944
AP5S1
AP-5 complex subunit sigma-1.
    
 
 0.931
SPG7
Paraplegin isoform X1.
      
 0.797
ALS2
Amyotrophic lateral sclerosis 2 protein.
      
 0.706
ATXN2
Ataxin-2 isoform X1.
   
  
 0.705
SPG21
Maspardin.
      
 0.702
VPS35
Vacuolar protein sorting-associated protein 35.
      
 0.695
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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