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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GEN1Flap endonuclease GEN homolog 1. (882 aa)    
Predicted Functional Partners:
WRN
Werner syndrome ATP-dependent helicase isoform X1.
  
 0.994
PCNA
Proliferating cell nuclear antigen isoform X1.
  
 0.870
DNA2
DNA replication ATP-dependent helicase/nuclease DNA2.
   
 0.856
MRE11
Double-strand break repair protein MRE11.
   
 0.820
MUS81
MUS81 structure-specific endonuclease subunit.
   
 0.781
ERCC3
LOW QUALITY PROTEIN: TFIIH basal transcription factor complex helicase XPB subunit.
   
 0.776
ENSPVIP00000020409
annotation not available
   
 0.769
FANCM
Fanconi anemia group M protein.
   
 0.769
GTF2H1
Transcription initiation factor TFIIH subunit 1.
    
 0.767
EME1
Crossover junction endonuclease EME1.
   
 0.764
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.