Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRS4Insulin receptor substrate 2. (960 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-binding protein 2.
    
 0.986
INS
Insulin.
    
 0.975
IGF1R
Insulin like growth factor 1 receptor.
    
 0.974
INSR
Insulin receptor.
    
 0.974
MTOR
Serine/threonine-protein kinase mTOR isoform X1.
    
 0.957
PTPN1
Protein tyrosine phosphatase non-receptor type 1.
    
 0.944
MAPK9
Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase).
    
 0.941
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.
    
 0.936
MAPK10
Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase).
    
 0.935
MAPK8
Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase).
    
 0.935
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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