Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
RNF216E3 ubiquitin-protein ligase RNF216 isoform X1. (913 aa)    
Predicted Functional Partners:
UBE2L3
Ubiquitin-conjugating enzyme E2 L3.
   
 0.934
RPS27A
Ribosomal protein S27a.
   
 0.927
RIPK1
Receptor-interacting serine/threonine-protein kinase 1 isoform X1.
    
 0.906
UBC
Polyubiquitin-C.
   
 0.905
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
   
 
 0.898
LOC110072527
Ubiquitin-large subunit ribosomal protein L40e.
    
  0.843
LOC110072526
Ubiquitin-large subunit ribosomal protein L40e.
    
  0.843
LOC110071729
Ubiquitin-conjugating enzyme E2 L3-like.
   
 0.781
TRAF3
TNF receptor-associated factor 3 isoform X1.
    
 0.725
ARC
Activity-regulated cytoskeleton-associated protein.
    
 
 0.711
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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