Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP73Tumor protein p73. (726 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53.
    
 0.982
ITCH
E3 ubiquitin-protein ligase Itchy homolog isoform X1.
    
 0.980
WWTR1
WW domain-containing transcription regulator protein 1.
    
 0.975
TP63
Tumor protein 63 isoform X1.
    
 0.972
MDM2
E3 ubiquitin-protein ligase Mdm2.
    
 0.967
EP300
Histone acetyltransferase p300 isoform X1.
    
 0.946
MDM4
MDM4 regulator of p53.
    
 0.939
RPS27A
Ribosomal protein S27a.
    
  0.917
NOXO1
NADPH oxidase organizer 1.
      
 0.850
WRN
Werner syndrome ATP-dependent helicase isoform X1.
    
 0.813
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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