Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CBLE3 ubiquitin-protein ligase CBL. (817 aa)    
Predicted Functional Partners:
MET
Hepatocyte growth factor receptor isoform X1.
    
 0.985
EGFR
Epidermal growth factor receptor.
    
 0.972
RAPGEF1
Rap guanine nucleotide exchange factor 1.
   
 0.966
SH2B2
SH2B adaptor protein 2.
    
 0.961
SH3KBP1
SH3 domain containing kinase binding protein 1.
    
 0.947
GRB2
Growth factor receptor-binding protein 2.
    
 0.936
INSR
Insulin receptor.
    
 0.926
CRK
LOW QUALITY PROTEIN: adapter molecule crk.
    
 0.925
CBLC
E3 ubiquitin-protein ligase CBL-C.
  
  
 
0.904
CBLB
E3 ubiquitin-protein ligase CBL-B isoform X1.
  
  
 
0.902
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.