Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RSPO2R-spondin 2. (241 aa)    
Predicted Functional Partners:
ZNRF3
Zinc and ring finger 3.
    
 0.993
LGR4
Leucine-rich repeat-containing G protein-coupled receptor 4.
   
 0.968
LGR5
Leucine-rich repeat-containing G protein-coupled receptor 5.
   
 0.959
RNF43
Ring finger protein 43.
    
 0.905
PJA2
E3 ubiquitin-protein ligase Praja-2 isoform X1.
    
 0.498
RNF126
E3 ubiquitin-protein ligase RNF115/126.
    
 0.498
RNF115
E3 ubiquitin-protein ligase RNF115/126.
    
 0.498
RNF215
RING finger protein 215.
    
 0.498
GDF9
Growth differentiation factor 9.
    
 0.493
CTNNB1
Catenin beta-1 isoform X1.
   
 
 0.444
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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