Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
WRNWerner syndrome ATP-dependent helicase isoform X1. (1482 aa)    
Predicted Functional Partners:
TOP3A
DNA topoisomerase 3-alpha.
  
 0.997
DNA2
DNA replication ATP-dependent helicase/nuclease DNA2.
   
 0.996
RAD52
DNA repair protein RAD52 homolog isoform X1.
   
 0.988
PCNA
Proliferating cell nuclear antigen isoform X1.
  
 0.985
BRCA1
Breast cancer type 1 susceptibility protein.
   
 0.983
RPA3
Replication protein A 14 kDa subunit.
    
 0.983
EXO1
Exonuclease 1 isoform X1.
  
 0.983
RPA1
Replication protein A 70 kDa DNA-binding subunit.
   
 0.980
MRE11
Double-strand break repair protein MRE11.
  
 0.978
XRCC5
X-ray repair cross-complementing protein 5.
   
 
 0.977
Your Current Organism:
Pogona vitticeps
NCBI taxonomy Id: 103695
Other names: P. vitticeps, ZMB 30101, central bearded dragon
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