STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGV00592.1Topoisomerase IV, subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (638 aa)    
Predicted Functional Partners:
EGV00591.1
COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit.
 
 
 0.992
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 
 0.987
EGV00291.1
DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI).
  
 
 0.661
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
     
 0.592
EGV00465.1
COG0592 DNA polymerase sliding clamp subunit (PCNA homolog).
  
 
 0.578
EGV00593.1
Hypothetical protein.
       0.561
EGV00588.1
Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
     
 0.546
EGV00207.1
Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
     
 0.529
EGV00590.1
COG0622 Predicted phosphoesterase.
       0.528
EGV00589.1
COG0561 Predicted hydrolases of the HAD superfamily.
       0.519
Your Current Organism:
Mycoplasma columbinum
NCBI taxonomy Id: 1037410
Other names: M. columbinum SF7, Mycoplasma columbinum SF7, Mycoplasma columbinum str. SF7, Mycoplasma columbinum strain SF7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.