STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGV00129.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (486 aa)    
Predicted Functional Partners:
dnaG
Putative DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
 0.997
EGV00268.1
Putative primosomal DNA helicase dnai; COG1484 DNA replication protein.
  
 
 0.991
dnaA
Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 
 0.918
EGV00127.1
Dhh subfamily 1 protein; COG3887 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain.
 
  
 0.860
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.859
EGV00291.1
DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI).
  
  
 0.847
EGV00130.1
COG1253 Hemolysins and related proteins containing CBS domains.
       0.816
tuf
Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
   0.798
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.705
EGV00063.1
COG0210 Superfamily I DNA and RNA helicases.
  
 
 0.666
Your Current Organism:
Mycoplasma columbinum
NCBI taxonomy Id: 1037410
Other names: M. columbinum SF7, Mycoplasma columbinum SF7, Mycoplasma columbinum str. SF7, Mycoplasma columbinum strain SF7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.