node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGV00186.1 | EGV00291.1 | MCSF7_01971 | MCSF7_00759 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | 0.925 |
EGV00186.1 | recA | MCSF7_01971 | MCSF7_00321 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.651 |
EGV00186.1 | recR | MCSF7_01971 | MCSF7_01491 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | Recombination protein recr; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.527 |
EGV00186.1 | ruvA | MCSF7_01971 | MCSF7_02066 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.605 |
EGV00186.1 | ruvB | MCSF7_01971 | MCSF7_02071 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.544 |
EGV00186.1 | topA | MCSF7_01971 | MCSF7_01831 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.942 |
EGV00207.1 | EGV00208.1 | MCSF7_02076 | MCSF7_02081 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Hypothetical protein; COG0196 FAD synthase. | 0.788 |
EGV00207.1 | EGV00291.1 | MCSF7_02076 | MCSF7_00759 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | 0.750 |
EGV00207.1 | recR | MCSF7_02076 | MCSF7_01491 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Recombination protein recr; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.490 |
EGV00207.1 | recU | MCSF7_02076 | MCSF7_03068 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Holliday junction-specific endonuclease; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. | 0.470 |
EGV00207.1 | ruvA | MCSF7_02076 | MCSF7_02066 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.774 |
EGV00207.1 | ruvB | MCSF7_02076 | MCSF7_02071 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.823 |
EGV00207.1 | topA | MCSF7_02076 | MCSF7_01831 | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.893 |
EGV00208.1 | EGV00207.1 | MCSF7_02081 | MCSF7_02076 | Hypothetical protein; COG0196 FAD synthase. | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.788 |
EGV00208.1 | EGV00291.1 | MCSF7_02081 | MCSF7_00759 | Hypothetical protein; COG0196 FAD synthase. | DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | 0.409 |
EGV00208.1 | ruvA | MCSF7_02081 | MCSF7_02066 | Hypothetical protein; COG0196 FAD synthase. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.538 |
EGV00208.1 | ruvB | MCSF7_02081 | MCSF7_02071 | Hypothetical protein; COG0196 FAD synthase. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.536 |
EGV00208.1 | topA | MCSF7_02081 | MCSF7_01831 | Hypothetical protein; COG0196 FAD synthase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.419 |
EGV00291.1 | EGV00186.1 | MCSF7_00759 | MCSF7_01971 | DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. | 0.925 |
EGV00291.1 | EGV00207.1 | MCSF7_00759 | MCSF7_02076 | DNA-directed DNA polymerase; COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | Bifunctional preprotein translocase subunit SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.750 |